| Acne Vulgaris
Tazorac vs Aklief
Side-by-side clinical, coverage, and cost comparison for acne vulgaris.Deep comparison between: Tazorac vs Aklief with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAklief has a higher rate of injection site reactions vs Tazorac based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Aklief but not Tazorac, including UnitedHealthcare
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Category
Tazorac
Aklief
At A Glance
Topical
Daily
Retinoid
Topical
Once daily
Retinoid (RAR agonist)
Indications
- Psoriasis vulgaris
- Acne Vulgaris
- Acne Vulgaris
Dosing
Psoriasis vulgaris Apply a thin film (2 mg/cm2) of 0.05% cream once daily in the evening to psoriatic lesions only; increase to 0.1% if tolerated and medically indicated.
Acne Vulgaris Apply a thin layer (2 mg/cm2) of 0.1% cream once daily in the evening to affected facial skin areas after gentle cleansing and drying.
Acne Vulgaris Apply a thin layer once daily in the evening to clean, dry skin; one pump actuation for the face, two for the upper trunk, with an optional additional actuation for the middle and lower back; avoid contact with eyes, lips, paranasal creases, and mucous membranes.
Contraindications
- Pregnancy (retinoids may cause fetal harm)
- Known hypersensitivity to any component of TAZORAC Cream
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Adverse Reactions
Most common (>=10%) Psoriasis: pruritus, erythema, burning; Acne: desquamation, dry skin, erythema, burning sensation
Serious Embryofetal toxicity, photosensitivity and risk of sunburn
Postmarketing Blister, dermatitis, urticaria, skin exfoliation, skin discoloration (hyperpigmentation or hypopigmentation), swelling at or near application sites, pain
Most common (>=1%) Application site irritation, application site pruritus, sunburn
Pharmacology
Tazarotene is a retinoid prodrug converted by esterase hydrolysis to tazarotenic acid, which binds retinoic acid receptors RAR-beta and RAR-gamma with relative selectivity and may modify gene expression in psoriatic and acne-affected skin.
Trifarotene is a retinoic acid receptor (RAR) agonist with particular activity at the gamma subtype; stimulation of RAR modulates target genes associated with cell differentiation and inflammation.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
No coverage data available for Tazorac.
Aklief
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
No coverage data available for Tazorac.
Aklief
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
No coverage data available for Tazorac.
Aklief
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Tazorac.
No savings programs available for Aklief.
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TazoracView full Tazorac profile
AkliefView full Aklief profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.