| Age related macular degeneration
Izervay vs Eylea HD
Side-by-side clinical, coverage, and cost comparison for age related macular degeneration.Deep comparison between: Izervay vs Eylea Hd with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEylea Hd has a higher rate of injection site reactions vs Izervay based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Eylea Hd but not Izervay, including UnitedHealthcare
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Category
Izervay
Eylea Hd
At A Glance
Intravitreal injection
Monthly
Complement C5 inhibitor
Intravitreal injection
Every 8-16 weeks
VEGF-A/PlGF inhibitor
Indications
- Age related macular degeneration
- Age related macular degeneration
- Macular edema due to diabetes mellitus
- Diabetic Retinopathy
- Retinal Vein Occlusion
Dosing
Age related macular degeneration 2 mg (0.1 mL of 20 mg/mL solution) by intravitreal injection to each affected eye once monthly (approximately every 28 +/- 7 days).
Age related macular degeneration, Macular edema due to diabetes mellitus 8 mg (0.07 mL) intravitreal injection every 4 weeks for 3 doses, then once every 8 to 16 weeks (+/- 1 week); extended dosing once every 20 weeks (+/- 1 week) may be considered after 1 year of successful response.
Diabetic Retinopathy 8 mg (0.07 mL) intravitreal injection every 4 weeks for 3 doses, then once every 8 to 12 weeks (+/- 1 week).
Retinal Vein Occlusion 8 mg (0.07 mL) intravitreal injection every 4 weeks for 3 to 5 doses, then once every 8 weeks (+/- 1 week).
Contraindications
- Ocular or periocular infections
- Active intraocular inflammation
- Ocular or periocular infections
- Active intraocular inflammation
- Known hypersensitivity to aflibercept or any excipient in EYLEA HD
Adverse Reactions
Most common (>=2%) Conjunctival hemorrhage, increased IOP, blurred vision, choroidal neovascularization, eye pain, vitreous floaters, blepharitis, punctate keratitis, retinal hemorrhage, ocular hypertension, corneal abrasion.
Serious Endophthalmitis, retinal detachment, photopsia, optic ischemic neuropathy, vitreous hemorrhage, vitritis (each reported in <=1% of patients).
Most common (>=3%) Cataract, conjunctival hemorrhage, corneal epithelium defect, intraocular pressure increased, ocular discomfort/eye pain/eye irritation, retinal hemorrhage, vision blurred, vitreous detachment, vitreous floaters
Serious Endophthalmitis, retinal detachments, retinal vasculitis with or without occlusion, increase in intraocular pressure, thromboembolic events
Postmarketing Retinal vasculitis, occlusive retinal vasculitis, scleritis
Pharmacology
Avacincaptad pegol is a PEGylated RNA aptamer that binds to and inhibits complement protein C5, preventing its cleavage to C5a and C5b and thereby decreasing membrane attack complex (MAC) formation.
Aflibercept acts as a soluble decoy receptor that binds VEGF-A and PlGF, inhibiting their binding and activation of VEGFR-1 and VEGFR-2, thereby suppressing neovascularization and vascular permeability in the eye.
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Most Common Insurance
Anthem BCBS
Izervay
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
Eylea Hd
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Izervay
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Eylea Hd
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Izervay
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Eylea Hd
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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IzervayView full Izervay profile
Eylea HdView full Eylea Hd profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.