| Allergic Conjunctivitis
Alrex vs Dextenza
Side-by-side clinical, coverage, and cost comparison for allergic conjunctivitis.Deep comparison between: Alrex vs Dextenza with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDextenza has a higher rate of injection site reactions vs Alrex based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Dextenza but not Alrex, including UnitedHealthcare
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Category
Alrex
Dextenza
At A Glance
Ophthalmic
Four times daily
Ophthalmic corticosteroid
Intracanalicular insert
Single insert (up to 30 days)
Corticosteroid
Indications
- Allergic Conjunctivitis
- Inflammatory abnormality of the eye
- Allergic Conjunctivitis
Dosing
Allergic Conjunctivitis One drop instilled into the affected eye(s) four times daily; shake vigorously before using.
Inflammatory abnormality of the eye, Allergic Conjunctivitis Single intracanalicular insert releasing 0.4 mg dexamethasone for up to 30 days, placed into the lower lacrimal canaliculus; resorbable, does not require removal.
Contraindications
- Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella
- Mycobacterial infection of the eye
- Fungal diseases of ocular structures
- Known or suspected hypersensitivity to any ingredient in this preparation or to other corticosteroids
- Active corneal, conjunctival, or canalicular infections, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, or varicella
- Mycobacterial infections of the eye
- Fungal diseases of the eye
- Dacryocystitis
Adverse Reactions
Most common (>=5%) abnormal vision/blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, photophobia
Serious elevated intraocular pressure, optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection, globe perforation
Other ocular (<5%) conjunctivitis, corneal abnormalities, eyelid erythema, keratoconjunctivitis, ocular irritation/pain/discomfort, papillae, uveitis
Non-ocular (<15%) headache, rhinitis, pharyngitis
Most common (>=1%) anterior chamber inflammation (including iritis and iridocyclitis), intraocular pressure increased, visual acuity reduced, cystoid macular edema, corneal edema, eye pain, conjunctival hyperemia, lacrimation increased, eye discharge, headache
Serious intraocular pressure increase, bacterial infection, viral infection, fungal infection, delayed healing
Pharmacology
Loteprednol etabonate is an ophthalmic corticosteroid that inhibits the inflammatory response by inducing phospholipase A2 inhibitory proteins (lipocortins), thereby reducing biosynthesis of prostaglandins and leukotrienes; it is structurally modified from prednisolone-related compounds to undergo predictable metabolism to inactive carboxylic acid metabolites.
Corticosteroid that suppresses inflammation by inhibiting multiple inflammatory cytokines, resulting in decreased edema, fibrin deposition, capillary leakage, and migration of inflammatory cells.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Alrex
- Covered on 5 commercial plans
- PA (8/12) · Step Therapy (0/12) · Qty limit (0/12)
Dextenza
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Alrex
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Dextenza
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Alrex
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Dextenza
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Alrex.
No savings programs available for Dextenza.
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DextenzaView full Dextenza profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.