| Angioedemas, Hereditary
Berinert vs Firazyr
Side-by-side clinical, coverage, and cost comparison for angioedemas, hereditary.Deep comparison between: Berinert vs Firazyr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFirazyr has a higher rate of injection site reactions vs Berinert based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Firazyr but not Berinert, including UnitedHealthcare
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Category
Berinert
Firazyr
At A Glance
IV injection
C1 esterase inhibitor
SC injection
As needed (up to 3 doses/24 hours)
Bradykinin B2 receptor antagonist
Indications
- Angioedemas, Hereditary
- Angioedemas, Hereditary
Dosing
Angioedemas, Hereditary 20 IU/kg body weight by slow intravenous injection; doses lower than 20 IU/kg body weight should not be administered.
Angioedemas, Hereditary 30 mg SC injection in the abdominal area; additional injections of 30 mg may be given at intervals of at least 6 hours if response is inadequate or symptoms recur; no more than 3 doses in any 24-hour period.
Contraindications
- Life-threatening hypersensitivity reactions, including anaphylaxis, to C1 esterase inhibitor preparations
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Adverse Reactions
Most common (>4%) Dysgeusia
Serious Laryngeal edema, facial HAE attacks with laryngeal edema, swelling, exacerbation of hereditary angioedema, laryngospasm
Postmarketing Hypersensitivity/anaphylactic reactions, injection-site pain, injection-site redness, chills, fever, thromboembolism (including basilar artery thrombosis, pulmonary microemboli)
Most common (>1%) Injection site reactions, pyrexia, transaminase increased, dizziness, rash, nausea, headache
Postmarketing Urticaria
Pharmacology
C1 esterase inhibitor is a plasma-derived serine protease inhibitor (serpin) that inhibits C1r, C1s, factor XIIa, kallikrein, and factor XIa, regulating the complement, contact (intrinsic coagulation), fibrinolytic, and coagulation cascades; IV replacement in C1-INH-deficient HAE patients suppresses bradykinin generation and reduces vascular permeability.
Bradykinin B2 receptor antagonist; icatibant competitively inhibits bradykinin from binding the B2 receptor, blocking the vasodilation, inflammation, and pain associated with bradykinin release in acute HAE attacks caused by C1-esterase-inhibitor deficiency or dysfunction.
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Most Common Insurance
Anthem BCBS
Berinert
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Firazyr
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (8/12) · Qty limit (9/12)
UnitedHealthcare
Berinert
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (3/8) · Qty limit (0/8)
Firazyr
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Berinert
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Firazyr
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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BerinertView full Berinert profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.