| Angioedemas, Hereditary
Ruconest vs Firazyr
Side-by-side clinical, coverage, and cost comparison for angioedemas, hereditary.Deep comparison between: Ruconest vs Firazyr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsFirazyr has a higher rate of injection site reactions vs Ruconest based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Firazyr but not Ruconest, including UnitedHealthcare
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Category
Ruconest
Firazyr
At A Glance
IV injection
As needed (up to 2 doses/24 hours)
C1 esterase inhibitor (recombinant)
SC injection
As needed (up to 3 doses/24 hours)
Bradykinin B2 receptor antagonist
Indications
- Angioedemas, Hereditary
- Angioedemas, Hereditary
Dosing
Angioedemas, Hereditary 50 U/kg IV (max 4200 U) by slow intravenous injection over approximately 5 minutes; a second dose at the same level may be given if symptoms persist; no more than 2 doses within 24 hours.
Angioedemas, Hereditary 30 mg SC injection in the abdominal area; additional injections of 30 mg may be given at intervals of at least 6 hours if response is inadequate or symptoms recur; no more than 3 doses in any 24-hour period.
Contraindications
- History of allergy to rabbits or rabbit-derived products
- History of life-threatening immediate hypersensitivity reactions to C1 esterase inhibitor preparations, including anaphylaxis
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Adverse Reactions
Most common (>=2%) Headache, nausea, diarrhea
Serious Anaphylaxis
Postmarketing Abdominal pain, rash
Most common (>1%) Injection site reactions, pyrexia, transaminase increased, dizziness, rash, nausea, headache
Postmarketing Urticaria
Pharmacology
Recombinant C1 esterase inhibitor (C1INH) that regulates the complement and contact system pathways by irreversibly binding target proteases (activated C1s, kallikrein, factor XIIa, factor XIa), restoring functional C1INH activity and suppressing the bradykinin-mediated vascular permeability increases that underlie HAE attacks.
Bradykinin B2 receptor antagonist; icatibant competitively inhibits bradykinin from binding the B2 receptor, blocking the vasodilation, inflammation, and pain associated with bradykinin release in acute HAE attacks caused by C1-esterase-inhibitor deficiency or dysfunction.
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Most Common Insurance
Anthem BCBS
Ruconest
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (3/12) · Qty limit (9/12)
Firazyr
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (8/12) · Qty limit (9/12)
UnitedHealthcare
Ruconest
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (4/8)
Firazyr
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Ruconest
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (2/3)
Firazyr
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Hereditary Angioedema - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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RuconestView full Ruconest profile
FirazyrView full Firazyr profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.