| Anthrax disease
Anthim vs Targadox
Side-by-side clinical, coverage, and cost comparison for anthrax disease.Deep comparison between: Anthim vs Targadox with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTargadox has a higher rate of injection site reactions vs Anthim based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Targadox but not Anthim, including UnitedHealthcare
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Category
Anthim
Targadox
At A Glance
IV infusion
Single dose
Anti-PA monoclonal antibody
Oral
Daily to twice daily
Tetracycline antibiotic
Indications
- Anthrax disease
- Rocky Mountain Spotted Fever
- TYPHUS
- Q Fever
- Rickettsialpox
- Respiratory Tract Infections
- Respiratory Tract Infections
- Upper Respiratory Infections
- Urinary tract infection
- Lymphogranuloma Venereum
- Psittacosis
- Trachoma
- Inclusion conjunctivitis
- Urethritis
- Uterine Cervicitis
- Proctitis
- non-gonococcal urethritis (NGU)
- Relapsing Fever
- Chancroid
- Plague
- Tularemia
- Cholera
- Campylobacter infection
- Brucellosis
- Bartonella Infections
- Granuloma Inguinale
- Anthrax disease
- Gonorrhea
- Syphilis
- Yaws
- Listeriosis
- Necrotizing Ulcerative Gingivitis
- Actinomycosis
- Clostridium Infections
- Amebiasis
- Acne Vulgaris
- Malaria
Dosing
Anthrax disease Adults: single 16 mg/kg IV infusion over 90 minutes; pediatric patients >40 kg: 16 mg/kg, >15-40 kg: 24 mg/kg, <=15 kg: 32 mg/kg, as single IV infusion over 90 minutes; pre-medicate with diphenhydramine.
Adults (general infections) 200 mg on day 1 (100 mg every 12 hours), then 100 mg/day maintenance; 100 mg every 12 hours for severe or chronic Urinary tract infection.
Pediatric patients <45 kg (severe infections) 2.2 mg/kg every 12 hours; for less severe disease (>8 years, <45 kg): 4.4 mg/kg divided into two doses on day 1, then 2.2 mg/kg/day as a single or divided dose. Children >=45 kg receive the adult dose.
Gonorrhea 100 mg twice daily for 7 days; alternate single-visit dose: 300 mg followed by 300 mg 1 hour later, may be taken with food or beverage.
Urethritis, Uterine Cervicitis, Proctitis, non-gonococcal urethritis (NGU) 100 mg twice daily for 7 days.
Syphilis (early, penicillin-allergic patients) 100 mg twice daily for 2 weeks.
Syphilis (>1 year duration, penicillin-allergic patients) 100 mg twice daily for 4 weeks.
Malaria (prophylaxis) Adults: 100 mg once daily beginning 1-2 days before travel, continuing during travel, and for 4 weeks after leaving the malarious area. Pediatric patients >8 years: 2 mg/kg once daily up to the adult dose.
Anthrax disease (inhalational, post-exposure) Adults: 100 mg twice daily for 60 days. Children <45 kg: 2.2 mg/kg twice daily for 60 days; children >=45 kg receive the adult dose.
Contraindications
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- Hypersensitivity to any of the tetracyclines
Adverse Reactions
Most common (>=1.5%) headache, pruritus, upper respiratory tract infections, cough, vessel puncture site bruise, infusion site swelling, urticaria, nasal congestion, infusion site pain, pain in extremity
Serious hypersensitivity, anaphylaxis
Most common Nausea, vomiting, diarrhea, anorexia, glossitis, dysphagia, enterocolitis, maculopapular and erythematous rashes.
Serious Toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylaxis, anaphylactoid purpura, DRESS, intracranial hypertension, hemolytic anemia, thrombocytopenia, hepatotoxicity, esophagitis, esophageal ulceration, permanent tooth discoloration.
Pharmacology
Obiltoxaximab is a monoclonal antibody that binds the protective antigen (PA) of B. anthracis, inhibiting its binding to cellular receptors and preventing intracellular entry of anthrax lethal factor and edema factor, the enzymatic toxin components responsible for the pathogenic effects of anthrax toxin.
Tetracycline-class antibacterial; doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, exhibiting bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
No coverage data available for Anthim.
Targadox
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (9/12) · Qty limit (10/12)
UnitedHealthcare
No coverage data available for Anthim.
Targadox
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
No coverage data available for Anthim.
Targadox
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Anthim.
No savings programs available for Targadox.
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AnthimView full Anthim profile
TargadoxView full Targadox profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.