| Asthma
Arnuity Ellipta vs Dulera
Side-by-side clinical, coverage, and cost comparison for asthma.Deep comparison between: Arnuity Ellipta vs Dulera with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDulera has a higher rate of injection site reactions vs Arnuity Ellipta based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Dulera but not Arnuity Ellipta, including UnitedHealthcare
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Category
Arnuity Ellipta
Dulera
At A Glance
Oral inhalation
Once daily
Inhaled corticosteroid
Oral inhalation
Twice daily
ICS/LABA combination
Indications
- Asthma
- Asthma
Dosing
Asthma (>=12 years) 1 actuation of ARNUITY ELLIPTA 100 mcg or 200 mcg once daily by oral inhalation; starting dosage based on prior asthma therapy and disease severity; maximum 200 mcg once daily.
Asthma (5-11 years) 1 actuation of ARNUITY ELLIPTA 50 mcg once daily by oral inhalation.
Asthma (>=12 years) 2 inhalations twice daily of DULERA 100 mcg/5 mcg or 200 mcg/5 mcg via oral inhalation; maximum 2 inhalations of 200 mcg/5 mcg twice daily (800 mcg/20 mcg per day).
Asthma (5 to <12 years) 2 inhalations of DULERA 50 mcg/5 mcg twice daily via oral inhalation; maximum daily dose 200 mcg/20 mcg.
Contraindications
- Primary treatment of status asthmaticus or other acute episodes of asthma requiring intensive measures
- Severe hypersensitivity to milk proteins or demonstrated hypersensitivity to fluticasone furoate or any excipient
- Primary treatment of status asthmaticus or acute episodes of asthma requiring intensive measures
- Known hypersensitivity to mometasone furoate, formoterol fumarate, or any ingredient in DULERA
Adverse Reactions
Most common (>=3%) Nasopharyngitis, headache, bronchitis, upper respiratory tract infection, pharyngitis, sinusitis, oral candidiasis, oropharyngeal candidiasis, oropharyngeal pain, toothache, gastroenteritis viral
Serious Hypertension, abscess, breast cancer, traumatic limb amputation, subarachnoid hemorrhage, intervertebral disc protrusion
Postmarketing Anaphylaxis, angioedema, rash, urticaria
Most common (>=3%) Nasopharyngitis, sinusitis, headache; dysphonia reported at 4-5% in long-term (52-week) treatment; influenza, upper respiratory tract infection in pediatric patients aged 5 to <12 years.
Serious Serious asthma-related events (hospitalizations, intubations, death), cardiovascular and CNS effects, Candida albicans infection, immunosuppression, hypercorticism and adrenal suppression, growth effects in pediatrics, glaucoma and cataracts.
Postmarketing Angina pectoris, cardiac arrhythmias (atrial fibrillation, ventricular extrasystoles, tachyarrhythmia), vision blurred, anaphylactic reaction, angioedema, severe hypotension, rash, pruritus, QT prolongation, blood pressure increased, hypokalemia, hyperglycemia, asthma aggravation (cough, dyspnea, wheezing, bronchospasm).
Pharmacology
Fluticasone furoate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity that binds the human glucocorticoid receptor with high affinity (approximately 29.9 times that of dexamethasone), inhibiting pro-inflammatory transcription factors such as NFkB and mediators involved in asthma pathogenesis.
DULERA combines mometasone furoate, a synthetic corticosteroid with potent anti-inflammatory activity that inhibits multiple cell types and inflammatory mediators involved in the asthmatic response, and formoterol fumarate, a selective long-acting beta2-adrenergic receptor agonist (LABA) that relaxes bronchial smooth muscle by stimulating adenyl cyclase and inhibiting mast cell mediator release.
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Most Common Insurance
Anthem BCBS
Arnuity Ellipta
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (5/12) · Qty limit (11/12)
Dulera
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (10/12)
UnitedHealthcare
Arnuity Ellipta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (8/8)
Dulera
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Arnuity Ellipta
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Dulera
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Arnuity Ellipta.
No savings programs available for Dulera.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.