| Asthma
Dulera vs Tezspire
Side-by-side clinical, coverage, and cost comparison for asthma.Deep comparison between: Dulera vs Tezspire with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTezspire has a higher rate of injection site reactions vs Dulera based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tezspire but not Dulera, including UnitedHealthcare
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Category
Dulera
Tezspire
At A Glance
Oral inhalation
Twice daily
ICS/LABA combination
SC injection
Every 4 weeks
TSLP blocker
Indications
- Asthma
- Asthma
- Chronic rhinosinusitis with multiple nasal polyps
Dosing
Asthma (>=12 years) 2 inhalations twice daily of DULERA 100 mcg/5 mcg or 200 mcg/5 mcg via oral inhalation; maximum 2 inhalations of 200 mcg/5 mcg twice daily (800 mcg/20 mcg per day).
Asthma (5 to <12 years) 2 inhalations of DULERA 50 mcg/5 mcg twice daily via oral inhalation; maximum daily dose 200 mcg/20 mcg.
Asthma, Chronic rhinosinusitis with multiple nasal polyps 210 mg administered subcutaneously once every 4 weeks.
Contraindications
- Primary treatment of status asthmaticus or acute episodes of asthma requiring intensive measures
- Known hypersensitivity to mometasone furoate, formoterol fumarate, or any ingredient in DULERA
- Known hypersensitivity to tezepelumab-ekko or any of its excipients
Adverse Reactions
Most common (>=3%) Nasopharyngitis, sinusitis, headache; dysphonia reported at 4-5% in long-term (52-week) treatment; influenza, upper respiratory tract infection in pediatric patients aged 5 to <12 years.
Serious Serious asthma-related events (hospitalizations, intubations, death), cardiovascular and CNS effects, Candida albicans infection, immunosuppression, hypercorticism and adrenal suppression, growth effects in pediatrics, glaucoma and cataracts.
Postmarketing Angina pectoris, cardiac arrhythmias (atrial fibrillation, ventricular extrasystoles, tachyarrhythmia), vision blurred, anaphylactic reaction, angioedema, severe hypotension, rash, pruritus, QT prolongation, blood pressure increased, hypokalemia, hyperglycemia, asthma aggravation (cough, dyspnea, wheezing, bronchospasm).
Most common (>=3%) Nasopharyngitis, upper respiratory tract infection, pharyngitis, arthralgia, back pain, epistaxis, influenza, injection site reaction
Serious Serious cardiac adverse events (incidence rate 1.08 per 100 patient-years in TEZSPIRE vs 0.21 in placebo in long-term extension trial)
Postmarketing Anaphylaxis
Pharmacology
DULERA combines mometasone furoate, a synthetic corticosteroid with potent anti-inflammatory activity that inhibits multiple cell types and inflammatory mediators involved in the asthmatic response, and formoterol fumarate, a selective long-acting beta2-adrenergic receptor agonist (LABA) that relaxes bronchial smooth muscle by stimulating adenyl cyclase and inhibiting mast cell mediator release.
TSLP blocker; tezepelumab-ekko is a human monoclonal antibody (IgG2lambda) that binds human thymic stromal lymphopoietin (TSLP) and blocks its interaction with the heterodimeric TSLP receptor, thereby reducing inflammatory biomarkers including blood eosinophils, IgE, FeNO, IL-5, and IL-13.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Dulera
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (10/12)
Tezspire
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Dulera
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Tezspire
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (4/8) · Qty limit (0/8)
Humana
Dulera
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (3/3)
Tezspire
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Dulera.
Cost estimate not availableAccessia Health: Asthma - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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DuleraView full Dulera profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.