| Atherosclerosis
Crestor vs Nexlizet
Side-by-side clinical, coverage, and cost comparison for atherosclerosis.Deep comparison between: Crestor vs Nexlizet with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNexlizet has a higher rate of injection site reactions vs Crestor based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nexlizet but not Crestor, including UnitedHealthcare
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Category
Crestor
Nexlizet
At A Glance
Oral
Once daily
HMG-CoA reductase inhibitor
Oral
Daily
ACL inhibitor / cholesterol absorption inhibitor
Indications
- Cardiovascular Diseases
- Hyperlipidemia
- Atherosclerosis
- Hypercholesterolemia, Familial
- Hypertriglyceridemia
- Hypercholesterolemia
- Atherosclerosis
Dosing
Cardiovascular Diseases, Hyperlipidemia, Atherosclerosis, Hypertriglyceridemia 5-40 mg orally once daily in adults.
Hypercholesterolemia, Familial HeFH: 5-10 mg once daily (ages 8 to <10 years) or 5-20 mg once daily (ages 10+); HoFH: 20 mg once daily (ages 7+); adults: 5-40 mg once daily.
Hypercholesterolemia, Atherosclerosis One tablet (180 mg bempedoic acid and 10 mg ezetimibe) orally once daily, with or without food.
Coadministration with bile acid sequestrants Administer at least 2 hours before or at least 4 hours after bile acid sequestrants.
Contraindications
- Acute liver failure or decompensated cirrhosis
- Hypersensitivity to rosuvastatin or any excipient in CRESTOR
- Prior hypersensitivity to ezetimibe or bempedoic acid or any of the excipients in NEXLIZET
Adverse Reactions
Most common (>=2%) headache, nausea, myalgia, asthenia, constipation, arthralgia, dizziness, increased CPK, abdominal pain, diabetes mellitus
Serious myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, hepatic dysfunction, proteinuria, hematuria, increases in HbA1c and fasting serum glucose
Postmarketing thrombocytopenia, hepatitis, jaundice, hepatic failure, peripheral neuropathy, cognitive impairment, myasthenia gravis, depression, sleep disorders, gynecomastia, interstitial lung disease, DRESS, lichenoid drug eruption
Most common (>=2%) Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes, diarrhea, arthralgia, sinusitis, fatigue, influenza
Serious Hyperuricemia, tendon rupture
Postmarketing Thrombocytopenia, abdominal pain, pancreatitis, nausea, hepatitis, cholelithiasis, cholecystitis, anaphylaxis, angioedema, myopathy/rhabdomyolysis, dizziness, paresthesia, depression, headache, erythema multiforme
Pharmacology
CRESTOR (rosuvastatin) is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate (a cholesterol precursor); inhibition accelerates hepatic LDL-receptor expression, reducing plasma LDL-C, total cholesterol, and VLDL levels.
NEXLIZET combines bempedoic acid, an ACL inhibitor that lowers LDL-C by blocking hepatic cholesterol synthesis upstream of HMG-CoA reductase via inhibition of ATP-citrate lyase, with ezetimibe, which reduces LDL-C by inhibiting intestinal cholesterol absorption via the NPC1L1 sterol transporter, together acting through complementary mechanisms to decrease circulating LDL-C.
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Most Common Insurance
Anthem BCBS
Crestor
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (0/12)
Nexlizet
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (11/12) · Qty limit (11/12)
UnitedHealthcare
Crestor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Nexlizet
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (6/8) · Qty limit (6/8)
Humana
Crestor
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Nexlizet
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Crestor.
No savings programs available for Nexlizet.
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Next Steps for Your Patient
CrestorView full Crestor profile
NexlizetView full Nexlizet profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.