| Attention deficit hyperactivity disorder
Azstarys vs Concerta
Side-by-side clinical, coverage, and cost comparison for attention deficit hyperactivity disorder.Deep comparison between: Azstarys vs Concerta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsConcerta has a higher rate of injection site reactions vs Azstarys based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Concerta but not Azstarys, including UnitedHealthcare
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Category
Azstarys
Concerta
At A Glance
Oral
Daily
CNS stimulant
Oral
Once daily
CNS stimulant
Indications
- Attention deficit hyperactivity disorder
- Attention deficit hyperactivity disorder
Dosing
Attention deficit hyperactivity disorder (ages 6-12) Starting dose 39.2 mg/7.8 mg orally once daily in the morning; may increase to 52.3 mg/10.4 mg or decrease to 26.1 mg/5.2 mg after one week; maximum 52.3 mg/10.4 mg once daily.
Attention deficit hyperactivity disorder (ages 13-17 and adults) Starting dose 39.2 mg/7.8 mg orally once daily in the morning; increase after one week to 52.3 mg/10.4 mg once daily depending on response and tolerability; maximum 52.3 mg/10.4 mg once daily.
Attention deficit hyperactivity disorder 18 mg once daily in the morning (adults may start at 18 or 36 mg); swallow whole; titrate by 18 mg weekly; max 54 mg/day (ages 6-12), 72 mg/day (ages 13-65).
Contraindications
- Known hypersensitivity to serdexmethylphenidate, methylphenidate, or other components of AZSTARYS
- Concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of MAOI treatment
- Known hypersensitivity to methylphenidate or other components of CONCERTA
- Concomitant use of monoamine oxidase inhibitors (MAOIs), or within 14 days following MAOI discontinuation
Adverse Reactions
Most common (>=5%) Decreased appetite, decreased weight, nausea, abdominal pain, dyspepsia, vomiting, insomnia, anxiety, affect lability, irritability, dizziness, increased blood pressure, tachycardia
Postmarketing Pancytopenia, thrombocytopenia, angina pectoris, bradycardia, supraventricular tachycardia, hepatocellular injury, acute hepatic failure, angioedema, anaphylactic reactions, urticaria, convulsion, serotonin syndrome, dyskinesia, hallucination, mania, rhabdomyolysis, priapism, Raynaud's phenomenon, alopecia
Most common (>=5%) Adults: decreased appetite, headache, dry mouth, nausea, insomnia, anxiety, dizziness, weight decreased, irritability, tachycardia, hyperhidrosis; pediatric patients 6 years and older: upper abdominal pain
Serious Hypersensitivity reactions (angioedema, anaphylaxis), hypertensive crisis with MAOIs, increased blood pressure and heart rate, psychiatric adverse reactions, priapism, peripheral vasculopathy including Raynaud's phenomenon, long-term growth suppression in pediatric patients
Postmarketing Pancytopenia, thrombocytopenia, angina pectoris, bradycardia, supraventricular tachycardia, hepatocellular injury, acute hepatic failure, convulsion, stroke, serotonin syndrome, hallucination, mania, priapism, alopecia, Raynaud's phenomenon, rhabdomyolysis
Pharmacology
CNS stimulant prodrug combination; serdexmethylphenidate is a prodrug of dexmethylphenidate, which blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space.
Methylphenidate is a CNS stimulant that blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space; its therapeutic mechanism in ADHD is not fully known.
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Most Common Insurance
Anthem BCBS
Azstarys
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
Concerta
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (10/12)
UnitedHealthcare
Azstarys
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (4/8) · Qty limit (5/8)
Concerta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Azstarys
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Concerta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Azstarys.
No savings programs available for Concerta.
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AzstarysView full Azstarys profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.