| Attention deficit hyperactivity disorder
Azstarys vs Dyanavel XR
Side-by-side clinical, coverage, and cost comparison for attention deficit hyperactivity disorder.Deep comparison between: Azstarys vs Dyanavel Xr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDyanavel Xr has a higher rate of injection site reactions vs Azstarys based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Dyanavel Xr but not Azstarys, including UnitedHealthcare
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Category
Azstarys
Dyanavel Xr
At A Glance
Oral
Daily
CNS stimulant
Oral
Once daily
CNS stimulant
Indications
- Attention deficit hyperactivity disorder
- Attention deficit hyperactivity disorder
Dosing
Attention deficit hyperactivity disorder (ages 6-12) Starting dose 39.2 mg/7.8 mg orally once daily in the morning; may increase to 52.3 mg/10.4 mg or decrease to 26.1 mg/5.2 mg after one week; maximum 52.3 mg/10.4 mg once daily.
Attention deficit hyperactivity disorder (ages 13-17 and adults) Starting dose 39.2 mg/7.8 mg orally once daily in the morning; increase after one week to 52.3 mg/10.4 mg once daily depending on response and tolerability; maximum 52.3 mg/10.4 mg once daily.
Attention deficit hyperactivity disorder Starting dose 2.5 mg or 5 mg once daily in the morning; may increase by 2.5-10 mg per day every 4-7 days based on clinical response; maximum 20 mg once daily.
Contraindications
- Known hypersensitivity to serdexmethylphenidate, methylphenidate, or other components of AZSTARYS
- Concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of MAOI treatment
- Known hypersensitivity to amphetamine or other components of DYANAVEL XR
- Concomitant use or within 14 days of stopping MAOIs (including linezolid or intravenous methylene blue) due to risk of hypertensive crisis
Adverse Reactions
Most common (>=5%) Decreased appetite, decreased weight, nausea, abdominal pain, dyspepsia, vomiting, insomnia, anxiety, affect lability, irritability, dizziness, increased blood pressure, tachycardia
Postmarketing Pancytopenia, thrombocytopenia, angina pectoris, bradycardia, supraventricular tachycardia, hepatocellular injury, acute hepatic failure, angioedema, anaphylactic reactions, urticaria, convulsion, serotonin syndrome, dyskinesia, hallucination, mania, rhabdomyolysis, priapism, Raynaud's phenomenon, alopecia
Most common (>=2%) Epistaxis, allergic rhinitis, upper abdominal pain (in pediatric patients aged 6-12 years in controlled trial)
Serious Palpitations, tachycardia, elevated blood pressure, sudden death, myocardial infarction, psychotic episodes, overstimulation, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, anaphylaxis
Postmarketing Rhabdomyolysis, Raynaud's phenomenon, intestinal ischemia, dermatillomania, bruxism, formication, frequent or prolonged erections, alopecia
Pharmacology
CNS stimulant prodrug combination; serdexmethylphenidate is a prodrug of dexmethylphenidate, which blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space.
Amphetamine is a non-catecholamine sympathomimetic amine CNS stimulant that blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space; the mode of therapeutic action in ADHD is not known.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Azstarys
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
Dyanavel Xr
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
UnitedHealthcare
Azstarys
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (4/8) · Qty limit (5/8)
Dyanavel Xr
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Azstarys
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Dyanavel Xr
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Azstarys.
No savings programs available for Dyanavel Xr.
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AzstarysView full Azstarys profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.