| Attention deficit hyperactivity disorder
Azstarys vs Qelbree
Side-by-side clinical, coverage, and cost comparison for attention deficit hyperactivity disorder.Deep comparison between: Azstarys vs Qelbree with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsQelbree has a higher rate of injection site reactions vs Azstarys based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Qelbree but not Azstarys, including UnitedHealthcare
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Category
Azstarys
Qelbree
At A Glance
Oral
Daily
CNS stimulant
Oral
Once daily
Selective norepinephrine reuptake inhibitor
Indications
- Attention deficit hyperactivity disorder
- Attention deficit hyperactivity disorder
Dosing
Attention deficit hyperactivity disorder (ages 6-12) Starting dose 39.2 mg/7.8 mg orally once daily in the morning; may increase to 52.3 mg/10.4 mg or decrease to 26.1 mg/5.2 mg after one week; maximum 52.3 mg/10.4 mg once daily.
Attention deficit hyperactivity disorder (ages 13-17 and adults) Starting dose 39.2 mg/7.8 mg orally once daily in the morning; increase after one week to 52.3 mg/10.4 mg once daily depending on response and tolerability; maximum 52.3 mg/10.4 mg once daily.
Attention deficit hyperactivity disorder (ages 6-11) 100 mg orally once daily; may titrate in increments of 100 mg weekly to a maximum of 400 mg once daily.
Attention deficit hyperactivity disorder (ages 12-17) 200 mg orally once daily; may titrate after 1 week by 200 mg to a maximum of 400 mg once daily.
Attention deficit hyperactivity disorder (adults) 200 mg orally once daily; may titrate in increments of 200 mg weekly to a maximum of 600 mg once daily.
Severe renal impairment 100 mg once daily; titrate in weekly increments of 50-100 mg to a maximum of 200 mg once daily.
Contraindications
- Known hypersensitivity to serdexmethylphenidate, methylphenidate, or other components of AZSTARYS
- Concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of MAOI treatment
- Concomitant treatment with monoamine oxidase inhibitors (MAOI), or within 14 days following discontinuing an MAOI, due to increased risk of hypertensive crisis
- Concomitant administration of sensitive CYP1A2 substrates or CYP1A2 substrates with a narrow therapeutic range
Adverse Reactions
Most common (>=5%) Decreased appetite, decreased weight, nausea, abdominal pain, dyspepsia, vomiting, insomnia, anxiety, affect lability, irritability, dizziness, increased blood pressure, tachycardia
Postmarketing Pancytopenia, thrombocytopenia, angina pectoris, bradycardia, supraventricular tachycardia, hepatocellular injury, acute hepatic failure, angioedema, anaphylactic reactions, urticaria, convulsion, serotonin syndrome, dyskinesia, hallucination, mania, rhabdomyolysis, priapism, Raynaud's phenomenon, alopecia
Most common (>=5%) - Pediatric (ages 6-17) Somnolence, decreased appetite, fatigue, nausea, vomiting, insomnia, irritability
Most common (>=5%) - Adults Insomnia, headache, somnolence, fatigue, nausea, decreased appetite, dry mouth, constipation
Serious Suicidal thoughts and behaviors, blood pressure and heart rate increases, activation of mania or hypomania, somnolence and fatigue
Pharmacology
CNS stimulant prodrug combination; serdexmethylphenidate is a prodrug of dexmethylphenidate, which blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space.
Viloxazine is a selective norepinephrine reuptake inhibitor that inhibits the norepinephrine transporter and exhibits partial agonist activity at the serotonin 5-HT2C receptor; its mechanism of action in ADHD is thought to be through inhibiting norepinephrine reuptake.
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Most Common Insurance
Anthem BCBS
Azstarys
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
Qelbree
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Azstarys
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (4/8) · Qty limit (5/8)
Qelbree
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Azstarys
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Qelbree
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Azstarys.
No savings programs available for Qelbree.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.