| Attention deficit hyperactivity disorder
Concerta vs Dyanavel XR
Side-by-side clinical, coverage, and cost comparison for attention deficit hyperactivity disorder.Deep comparison between: Concerta vs Dyanavel Xr with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDyanavel Xr has a higher rate of injection site reactions vs Concerta based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Dyanavel Xr but not Concerta, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Concerta
Dyanavel Xr
At A Glance
Oral
Once daily
CNS stimulant
Oral
Once daily
CNS stimulant
Indications
- Attention deficit hyperactivity disorder
- Attention deficit hyperactivity disorder
Dosing
Attention deficit hyperactivity disorder 18 mg once daily in the morning (adults may start at 18 or 36 mg); swallow whole; titrate by 18 mg weekly; max 54 mg/day (ages 6-12), 72 mg/day (ages 13-65).
Attention deficit hyperactivity disorder Starting dose 2.5 mg or 5 mg once daily in the morning; may increase by 2.5-10 mg per day every 4-7 days based on clinical response; maximum 20 mg once daily.
Contraindications
- Known hypersensitivity to methylphenidate or other components of CONCERTA
- Concomitant use of monoamine oxidase inhibitors (MAOIs), or within 14 days following MAOI discontinuation
- Known hypersensitivity to amphetamine or other components of DYANAVEL XR
- Concomitant use or within 14 days of stopping MAOIs (including linezolid or intravenous methylene blue) due to risk of hypertensive crisis
Adverse Reactions
Most common (>=5%) Adults: decreased appetite, headache, dry mouth, nausea, insomnia, anxiety, dizziness, weight decreased, irritability, tachycardia, hyperhidrosis; pediatric patients 6 years and older: upper abdominal pain
Serious Hypersensitivity reactions (angioedema, anaphylaxis), hypertensive crisis with MAOIs, increased blood pressure and heart rate, psychiatric adverse reactions, priapism, peripheral vasculopathy including Raynaud's phenomenon, long-term growth suppression in pediatric patients
Postmarketing Pancytopenia, thrombocytopenia, angina pectoris, bradycardia, supraventricular tachycardia, hepatocellular injury, acute hepatic failure, convulsion, stroke, serotonin syndrome, hallucination, mania, priapism, alopecia, Raynaud's phenomenon, rhabdomyolysis
Most common (>=2%) Epistaxis, allergic rhinitis, upper abdominal pain (in pediatric patients aged 6-12 years in controlled trial)
Serious Palpitations, tachycardia, elevated blood pressure, sudden death, myocardial infarction, psychotic episodes, overstimulation, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, anaphylaxis
Postmarketing Rhabdomyolysis, Raynaud's phenomenon, intestinal ischemia, dermatillomania, bruxism, formication, frequent or prolonged erections, alopecia
Pharmacology
Methylphenidate is a CNS stimulant that blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space; its therapeutic mechanism in ADHD is not fully known.
Amphetamine is a non-catecholamine sympathomimetic amine CNS stimulant that blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space; the mode of therapeutic action in ADHD is not known.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Concerta
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (9/12) · Qty limit (10/12)
Dyanavel Xr
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
UnitedHealthcare
Concerta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Dyanavel Xr
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Concerta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (3/3)
Dyanavel Xr
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Concerta.
No savings programs available for Dyanavel Xr.
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
ConcertaView full Concerta profile
Dyanavel XrView full Dyanavel Xr profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.