| Attention deficit hyperactivity disorder
Dyanavel XR vs Qelbree
Side-by-side clinical, coverage, and cost comparison for attention deficit hyperactivity disorder.Deep comparison between: Dyanavel Xr vs Qelbree with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsQelbree has a higher rate of injection site reactions vs Dyanavel Xr based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Qelbree but not Dyanavel Xr, including UnitedHealthcare
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Category
Dyanavel Xr
Qelbree
At A Glance
Oral
Once daily
CNS stimulant
Oral
Once daily
Selective norepinephrine reuptake inhibitor
Indications
- Attention deficit hyperactivity disorder
- Attention deficit hyperactivity disorder
Dosing
Attention deficit hyperactivity disorder Starting dose 2.5 mg or 5 mg once daily in the morning; may increase by 2.5-10 mg per day every 4-7 days based on clinical response; maximum 20 mg once daily.
Attention deficit hyperactivity disorder (ages 6-11) 100 mg orally once daily; may titrate in increments of 100 mg weekly to a maximum of 400 mg once daily.
Attention deficit hyperactivity disorder (ages 12-17) 200 mg orally once daily; may titrate after 1 week by 200 mg to a maximum of 400 mg once daily.
Attention deficit hyperactivity disorder (adults) 200 mg orally once daily; may titrate in increments of 200 mg weekly to a maximum of 600 mg once daily.
Severe renal impairment 100 mg once daily; titrate in weekly increments of 50-100 mg to a maximum of 200 mg once daily.
Contraindications
- Known hypersensitivity to amphetamine or other components of DYANAVEL XR
- Concomitant use or within 14 days of stopping MAOIs (including linezolid or intravenous methylene blue) due to risk of hypertensive crisis
- Concomitant treatment with monoamine oxidase inhibitors (MAOI), or within 14 days following discontinuing an MAOI, due to increased risk of hypertensive crisis
- Concomitant administration of sensitive CYP1A2 substrates or CYP1A2 substrates with a narrow therapeutic range
Adverse Reactions
Most common (>=2%) Epistaxis, allergic rhinitis, upper abdominal pain (in pediatric patients aged 6-12 years in controlled trial)
Serious Palpitations, tachycardia, elevated blood pressure, sudden death, myocardial infarction, psychotic episodes, overstimulation, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, anaphylaxis
Postmarketing Rhabdomyolysis, Raynaud's phenomenon, intestinal ischemia, dermatillomania, bruxism, formication, frequent or prolonged erections, alopecia
Most common (>=5%) - Pediatric (ages 6-17) Somnolence, decreased appetite, fatigue, nausea, vomiting, insomnia, irritability
Most common (>=5%) - Adults Insomnia, headache, somnolence, fatigue, nausea, decreased appetite, dry mouth, constipation
Serious Suicidal thoughts and behaviors, blood pressure and heart rate increases, activation of mania or hypomania, somnolence and fatigue
Pharmacology
Amphetamine is a non-catecholamine sympathomimetic amine CNS stimulant that blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases release of these monoamines into the extraneuronal space; the mode of therapeutic action in ADHD is not known.
Viloxazine is a selective norepinephrine reuptake inhibitor that inhibits the norepinephrine transporter and exhibits partial agonist activity at the serotonin 5-HT2C receptor; its mechanism of action in ADHD is thought to be through inhibiting norepinephrine reuptake.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Dyanavel Xr
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
Qelbree
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
UnitedHealthcare
Dyanavel Xr
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Qelbree
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Dyanavel Xr
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (2/3)
Qelbree
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Dyanavel Xr.
No savings programs available for Qelbree.
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Dyanavel XrView full Dyanavel Xr profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.