| Attention deficit hyperactivity disorder
Qelbree vs Quillivant XR
Side-by-side clinical, coverage, and cost comparison for attention deficit hyperactivity disorder.Deep comparison between: Qelbree vs Quillivant with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsQuillivant has a higher rate of injection site reactions vs Qelbree based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Quillivant but not Qelbree, including UnitedHealthcare
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Category
Qelbree
Quillivant
At A Glance
Oral
Once daily
Selective norepinephrine reuptake inhibitor
Oral
Daily
CNS stimulant
Indications
- Attention deficit hyperactivity disorder
- Attention deficit hyperactivity disorder
Dosing
Attention deficit hyperactivity disorder (ages 6-11) 100 mg orally once daily; may titrate in increments of 100 mg weekly to a maximum of 400 mg once daily.
Attention deficit hyperactivity disorder (ages 12-17) 200 mg orally once daily; may titrate after 1 week by 200 mg to a maximum of 400 mg once daily.
Attention deficit hyperactivity disorder (adults) 200 mg orally once daily; may titrate in increments of 200 mg weekly to a maximum of 600 mg once daily.
Severe renal impairment 100 mg once daily; titrate in weekly increments of 50-100 mg to a maximum of 200 mg once daily.
Attention deficit hyperactivity disorder Starting dose 20 mg once daily in the morning for patients 6 years and above; may titrate weekly in increments of 10 mg to 20 mg; daily doses above 60 mg have not been studied and are not recommended.
Contraindications
- Concomitant treatment with monoamine oxidase inhibitors (MAOI), or within 14 days following discontinuing an MAOI, due to increased risk of hypertensive crisis
- Concomitant administration of sensitive CYP1A2 substrates or CYP1A2 substrates with a narrow therapeutic range
- Hypersensitivity to methylphenidate or other components of QUILLIVANT XR
- Concomitant or recent (within 14 days) use of monoamine oxidase inhibitors (MAOIs)
Adverse Reactions
Most common (>=5%) - Pediatric (ages 6-17) Somnolence, decreased appetite, fatigue, nausea, vomiting, insomnia, irritability
Most common (>=5%) - Adults Insomnia, headache, somnolence, fatigue, nausea, decreased appetite, dry mouth, constipation
Serious Suicidal thoughts and behaviors, blood pressure and heart rate increases, activation of mania or hypomania, somnolence and fatigue
Most common (>=2%) affect lability, excoriation, initial insomnia, tic, decreased appetite, vomiting, motion sickness, eye pain, rash
Postmarketing pancytopenia, thrombocytopenia, angina pectoris, bradycardia, severe hepatocellular injury, angioedema, anaphylactic reactions, rhabdomyolysis, convulsion, dyskinesia, serotonin syndrome, hallucinations, mania, priapism, alopecia, Raynaud's phenomenon
Pharmacology
Viloxazine is a selective norepinephrine reuptake inhibitor that inhibits the norepinephrine transporter and exhibits partial agonist activity at the serotonin 5-HT2C receptor; its mechanism of action in ADHD is thought to be through inhibiting norepinephrine reuptake.
Methylphenidate is a CNS stimulant that blocks reuptake of norepinephrine and dopamine into the presynaptic neuron and increases the release of these monoamines into the extraneuronal space; the mode of therapeutic action in ADHD is not fully known.
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Most Common Insurance
Anthem BCBS
Qelbree
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (0/12)
Quillivant
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (10/12)
UnitedHealthcare
Qelbree
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Quillivant
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Qelbree
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Quillivant
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Qelbree.
No savings programs available for Quillivant.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.