| Bipolar I disorder
Abilify Asimtufii vs Lybalvi
Side-by-side clinical, coverage, and cost comparison for bipolar i disorder.Deep comparison between: Abilify Asimtufii vs Lybalvi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLybalvi has a higher rate of injection site reactions vs Abilify Asimtufii based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lybalvi but not Abilify Asimtufii, including UnitedHealthcare
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Category
Abilify Asimtufii
Lybalvi
At A Glance
IM injection
Every 2 months
Atypical antipsychotic
Oral
Once daily
Atypical antipsychotic + opioid antagonist
Indications
- Schizophrenia
- Bipolar I disorder
- Schizophrenia
- Bipolar I disorder
Dosing
Schizophrenia, Bipolar I disorder 960 mg IM gluteal injection once every 2 months (56 days); dose may be reduced to 720 mg if adverse reactions occur; CYP2D6 poor metabolizers: 720 mg once every 2 months.
Schizophrenia Initiate at 5 or 10 mg/10 mg orally once daily; recommended dose 10, 15, or 20 mg/10 mg once daily; maximum 20 mg/10 mg once daily.
Bipolar I disorder - monotherapy (manic or mixed episodes) Initiate at 10 or 15 mg/10 mg orally once daily; recommended dose 10, 15, or 20 mg/10 mg once daily; maximum 20 mg/10 mg once daily.
Bipolar I disorder - adjunct to lithium or valproate Initiate at 10 mg/10 mg orally once daily; recommended dose 10, 15, or 20 mg/10 mg once daily; maximum 20 mg/10 mg once daily.
Contraindications
- Known hypersensitivity to aripiprazole or any excipient
- Current opioid use
- Acute opioid withdrawal
Adverse Reactions
Most common (>=5%) Increased weight, akathisia, injection site pain, sedation
Serious Neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes, orthostatic hypotension, leukopenia/neutropenia/agranulocytosis, seizures, dysphagia
Postmarketing Anaphylactic reaction, angioedema, DRESS, blood glucose fluctuation, pathological gambling, fecal incontinence, hiccups
Most common (>=5%) Weight increased, somnolence, dry mouth, headache
Serious Neuroleptic malignant syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), metabolic changes (hyperglycemia, dyslipidemia, weight gain), tardive dyskinesia, orthostatic hypotension and syncope, leukopenia, neutropenia, agranulocytosis, dysphagia, seizures
Postmarketing Anaphylactoid reaction, angioedema, cholestatic or mixed liver injury, hepatitis, jaundice, diabetic coma, diabetic ketoacidosis, DRESS, fecal incontinence, hyperlipidemia, neutropenia, pancreatitis, priapism, rash, rhabdomyolysis, SIADH, somnambulism, stuttering, venous thromboembolic events
Pharmacology
Aripiprazole is an atypical antipsychotic whose efficacy may be mediated through partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors; the active metabolite dehydro-aripiprazole also has affinity for D2 receptors.
The efficacy of olanzapine in schizophrenia and bipolar I disorder may be mediated through combined dopamine and serotonin type 2 (5HT2) antagonism; samidorphan is an opioid antagonist whose mechanism could be mediated through mu-, kappa-, and delta-opioid receptor antagonism.
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Most Common Insurance
Anthem BCBS
Abilify Asimtufii
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (11/12)
Lybalvi
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (6/12) · Qty limit (10/12)
UnitedHealthcare
Abilify Asimtufii
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Lybalvi
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (1/8)
Humana
Abilify Asimtufii
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (3/3)
Lybalvi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$5/fillfill
Abilify Asimtufii Savings CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableHealthWell: Schizophrenia - Medicare Access
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Abilify AsimtufiiView full Abilify Asimtufii profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.