| Carcinoma breast stage IV
Arimidex vs Ixempra
Side-by-side clinical, coverage, and cost comparison for carcinoma breast stage iv.Deep comparison between: Arimidex vs Ixempra with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsIxempra has a higher rate of injection site reactions vs Arimidex based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Ixempra but not Arimidex, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Arimidex
Ixempra
At A Glance
Oral
Daily
Aromatase inhibitor
IV infusion
Every 3 weeks
Microtubule inhibitor (epothilone analog)
Indications
- Malignant neoplasm of breast
- Locally advanced breast cancer
- Carcinoma breast stage IV
- Carcinoma breast stage IV
- Locally advanced breast cancer
Dosing
Malignant neoplasm of breast 1 mg tablet orally once daily; adjuvant treatment duration in the ATAC trial was 5 years.
Locally advanced breast cancer, Carcinoma breast stage IV 1 mg tablet orally once daily; continue until tumor progression.
Carcinoma breast stage IV, Locally advanced breast cancer (with capecitabine) 40 mg/m2 IV over 3 hours every 3 weeks; capecitabine 1000 mg/m2 twice daily for 2 weeks per cycle.
Carcinoma breast stage IV, Locally advanced breast cancer (single agent) 40 mg/m2 IV over 3 hours every 3 weeks.
Contraindications
- Hypersensitivity to anastrozole or any excipient (including anaphylaxis, angioedema, and urticaria)
- Neutrophil count <1500 cells/mm3 or platelet count <100,000 cells/mm3
- History of severe hypersensitivity to agents containing Cremophor EL or its derivatives (e.g., polyoxyethylated castor oil)
- Combination with capecitabine in patients with AST or ALT >2.5 x ULN or bilirubin >1 x ULN
Adverse Reactions
Most common (>=10%) Hot flashes, asthenia, arthritis, pain, arthralgia, hypertension, depression, nausea and vomiting, rash, osteoporosis, fractures, back pain, insomnia, headache, bone pain, peripheral edema, increased cough, dyspnea, pharyngitis, lymphedema
Serious Skin lesions, ulcers, or blisters; severe allergic reactions with swelling of face, lips, tongue, and/or throat; liver function abnormalities including hepatitis
Postmarketing Hepatobiliary events (increases in alkaline phosphatase, ALT, AST, gamma-GT, and bilirubin; hepatitis), erythema multiforme, Stevens-Johnson syndrome, angioedema, urticaria, anaphylaxis, myalgia, hypercalcemia, tendon disorders including tendon rupture and tendonitis
Most common (>=20%) Peripheral sensory neuropathy, fatigue/asthenia, myalgia/arthralgia, alopecia, nausea, vomiting, stomatitis/mucositis, diarrhea, musculoskeletal pain; in combination therapy also: palmar-plantar erythrodysesthesia, anorexia, abdominal pain, nail disorder, constipation.
Most common hematologic (>40%) Neutropenia, leukopenia, anemia, thrombocytopenia.
Serious Peripheral neuropathy, myelosuppression, hypersensitivity reactions, cardiac adverse reactions (myocardial infarction, arrhythmia, left ventricular dysfunction), sepsis, pneumonia, respiratory failure, acute hepatic failure.
Postmarketing Radiation recall.
Pharmacology
Anastrozole is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by blocking the aromatase enzyme, significantly lowering serum estradiol concentrations in postmenopausal women without affecting adrenal corticosteroid or aldosterone formation.
Ixabepilone is a semi-synthetic analog of epothilone B that binds directly to beta-tubulin subunits on microtubules, suppressing microtubule dynamic instability and blocking cells in the mitotic phase of the cell division cycle, leading to cell death.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Arimidex
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (0/12)
Ixempra
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Arimidex
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Ixempra
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Arimidex
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (2/3)
Ixempra
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Breast Cancer
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Breast Cancer
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
ArimidexView full Arimidex profile
IxempraView full Ixempra profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.