| Central Precocious Puberty
Fensolvi vs Supprelin LA
Side-by-side clinical, coverage, and cost comparison for central precocious puberty.Deep comparison between: Fensolvi vs Supprelin with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSupprelin has a higher rate of injection site reactions vs Fensolvi based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Supprelin but not Fensolvi, including UnitedHealthcare
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Category
Fensolvi
Supprelin
At A Glance
SC injection
Every 6 months
GnRH agonist
SC implant
Every 12 months
GnRH agonist
Indications
- Central Precocious Puberty
- Central Precocious Puberty
Dosing
Central Precocious Puberty 45 mg by subcutaneous injection once every six months; discontinue at the appropriate age of onset of puberty.
Central Precocious Puberty One subcutaneous implant (50 mg histrelin acetate) inserted in the inner aspect of the upper arm every 12 months, providing continuous release of 65 mcg/day; remove after 12 months and replace if continued therapy is indicated.
Contraindications
- Hypersensitivity to GnRH, GnRH agonists, or any component of FENSOLVI
- Pregnancy (FENSOLVI may cause fetal harm)
- Hypersensitivity to gonadotropin releasing hormone (GnRH) or GnRH agonist analogs
- Pregnancy
Adverse Reactions
Most common (>=5%) Injection site pain, nasopharyngitis, pyrexia, headache, cough, abdominal pain, injection site erythema, nausea, constipation, vomiting, upper respiratory tract infection, bronchospasm, productive cough, hot flush
Serious Initial rise in gonadotropin and sex steroid levels, psychiatric events, convulsions, severe cutaneous adverse reactions, pseudotumor cerebri (idiopathic intracranial hypertension)
Postmarketing Anaphylaxis, rash, urticaria, chest pain, weight changes, decreased appetite, fatigue, decreased WBC, diabetes mellitus, arthralgia, epiphysiolysis, muscle spasms, myalgia, neuropathy, convulsion, paralysis, insomnia, emotional lability, depression, suicidal ideation, injection site reactions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, vaginal bleeding, breast enlargement, hypertension, hypotension, dyspnea
Most common Implant site reaction, keloid scar, scar, suture-related complication, application site pain, post-procedural pain
Serious Initial agonist action, implant breakage, psychiatric events, convulsions, severe cutaneous adverse reactions, pseudotumor cerebri
Postmarketing Implant breakage, emotional lability, depression, seizures, pseudotumor cerebri, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis
Pharmacology
GnRH agonist that suppresses gonadotropin secretion (LH and FSH) through chronic downregulation of GnRH receptors, reducing gonadal production of estradiol and testosterone; this inhibitory effect is reversible upon discontinuation.
GnRH agonist; continuous subcutaneous delivery of histrelin acetate desensitizes pituitary gonadotropin responsiveness via down-regulation of GnRH receptors in the pituitary gland, resulting in decreased LH and FSH levels and reduced gonadal steroidogenesis.
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Most Common Insurance
Anthem BCBS
Fensolvi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Supprelin
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
UnitedHealthcare
Fensolvi
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Supprelin
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Fensolvi
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (2/3)
Supprelin
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$5/fillfill
Fensolvi TotalSolutions Copay AssistanceCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Supprelin.
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FensolviView full Fensolvi profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.