| Chemotherapy-induced nausea and vomiting
Sancuso vs Varubi
Side-by-side clinical, coverage, and cost comparison for chemotherapy-induced nausea and vomiting.Deep comparison between: Sancuso vs Varubi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVarubi has a higher rate of injection site reactions vs Sancuso based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Varubi but not Sancuso, including UnitedHealthcare
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Category
Sancuso
Varubi
At A Glance
Transdermal
Single patch, up to 7 days
5-HT3 receptor antagonist
Oral
Once per chemotherapy cycle
NK1 receptor antagonist
Indications
- Chemotherapy-induced nausea and vomiting
- Chemotherapy-induced nausea and vomiting
Dosing
Chemotherapy-induced nausea and vomiting Apply a single transdermal system to the upper outer arm 24-48 hours before chemotherapy; wear for at minimum 24 hours after chemotherapy is completed, up to 7 days total; each system releases 3.1 mg granisetron per 24 hours.
Chemotherapy-induced nausea and vomiting 180 mg as a single oral dose within 2 hours prior to initiation of chemotherapy, in combination with a 5-HT3 receptor antagonist and dexamethasone; administer at no less than 2-week intervals per chemotherapy cycle.
Contraindications
- Known hypersensitivity to granisetron or any component of the transdermal system
- Concomitant use with CYP2D6 substrates with a narrow therapeutic index such as thioridazine and pimozide, due to risk of QT prolongation and Torsades de Pointes
- Pediatric patients less than 2 years of age due to risk of irreversible impairment of sexual development and fertility
Adverse Reactions
Most common (>=3%) Constipation, headache
Serious Progressive ileus and gastric distention, serotonin syndrome, skin reactions, increased drug exposure with external heat sources, phototoxicity with ultraviolet light exposure
Postmarketing Application site reactions (pain, pruritus, erythema, rash, irritation, vesicles, burn, discoloration, urticaria), transdermal system non-adhesion, bradycardia, chest pain, palpitations, sick sinus syndrome
Most common (>=3%) Neutropenia, decreased appetite, dizziness, hiccups, dyspepsia, urinary tract infection, stomatitis, abdominal pain, anemia
Pharmacology
Granisetron is a selective 5-HT3 receptor antagonist that blocks serotonin-3 receptors located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone, preventing chemotherapy-induced serotonin release from stimulating the vomiting reflex.
Rolapitant is a selective and competitive antagonist of human substance P/NK1 receptors; it does not have significant affinity for NK2 or NK3 receptors or other receptors, transporters, enzymes, or ion channels, and is active in animal models of chemotherapy-induced emesis.
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Most Common Insurance
Anthem BCBS
Sancuso
- Covered on 5 commercial plans
- PA (4/12) · Step Therapy (1/12) · Qty limit (9/12)
Varubi
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (2/12) · Qty limit (9/12)
UnitedHealthcare
Sancuso
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (2/8)
Varubi
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Sancuso
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (3/3)
Varubi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Sancuso.
No savings programs available for Varubi.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.