| Chronic Lymphocytic Leukemia
Bendeka vs Calquence Tablets
Side-by-side clinical, coverage, and cost comparison for chronic lymphocytic leukemia.Deep comparison between: Bendeka vs Calquence with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCalquence has a higher rate of injection site reactions vs Bendeka based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Calquence but not Bendeka, including UnitedHealthcare
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Category
Bendeka
Calquence
At A Glance
IV infusion
Every 3-4 weeks
Alkylating agent
Oral
Every 12 hours
BTK inhibitor
Indications
- Chronic Lymphocytic Leukemia
- Indolent B-Cell Non-Hodgkin Lymphoma
- Mantle cell lymphoma
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
Dosing
Chronic Lymphocytic Leukemia 100 mg/m2 IV over 10 minutes on Days 1 and 2 of a 28-day cycle, up to 6 cycles.
Indolent B-Cell Non-Hodgkin Lymphoma 120 mg/m2 IV over 10 minutes on Days 1 and 2 of a 21-day cycle, up to 8 cycles.
Mantle cell lymphoma 100 mg orally approximately every 12 hours until disease progression or unacceptable toxicity; swallow tablet whole with or without food (monotherapy or in combination with bendamustine and rituximab).
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 100 mg orally approximately every 12 hours until disease progression or unacceptable toxicity (monotherapy, or in combination with obinutuzumab or venetoclax).
Contraindications
- Known hypersensitivity (e.g., anaphylactic and anaphylactoid reactions) to bendamustine, polyethylene glycol 400, propylene glycol, or monothioglycerol
—
Adverse Reactions
Most common (>=30%) Nausea, fatigue, vomiting, diarrhea, pyrexia
Serious Febrile neutropenia, pneumonia, acute renal failure, cardiac failure, hypersensitivity, skin reactions, pulmonary fibrosis, myelodysplastic syndrome
Postmarketing Pancytopenia, atrial fibrillation, congestive heart failure, myocardial infarction, anaphylaxis, progressive multifocal leukoencephalopathy, nephrogenic diabetes insipidus, pneumonitis, DRESS, non-melanoma skin cancer, Stevens-Johnson syndrome, toxic epidermal necrolysis
Most common (>=30%) Upper respiratory tract infection, diarrhea, headache, musculoskeletal pain.
Serious Serious and opportunistic infections, hemorrhage, cytopenias, second primary malignancies, cardiac arrhythmias, hepatotoxicity including drug-induced liver injury.
Postmarketing Ventricular arrhythmias, drug induced liver injury.
Pharmacology
Bendamustine is a bifunctional mechlorethamine derivative containing a benzimidazole ring that forms electrophilic alkyl groups, which create covalent interstrand DNA crosslinks leading to cell death via multiple pathways; it is active against both quiescent and dividing cells.
Acalabrutinib is a small-molecule inhibitor of Bruton tyrosine kinase (BTK); it and its active metabolite ACP-5862 form a covalent bond with a cysteine residue in the BTK active site, inhibiting BTK enzymatic activity and downstream B-cell proliferation, trafficking, chemotaxis, and adhesion pathways required for B-cell malignancy growth.
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Most Common Insurance
Anthem BCBS
Bendeka
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Calquence
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Bendeka
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Calquence
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Humana
Bendeka
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Calquence
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Bendeka.
Cost estimate not availableAssistance Fund: Chronic Lymphocytic Leukemia (CLL)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.