| Chronic Lymphocytic Leukemia
Bendeka vs Zydelig
Side-by-side clinical, coverage, and cost comparison for chronic lymphocytic leukemia.Deep comparison between: Bendeka vs Zydelig with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsZydelig has a higher rate of injection site reactions vs Bendeka based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Zydelig but not Bendeka, including UnitedHealthcare
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Category
Bendeka
Zydelig
At A Glance
IV infusion
Every 3-4 weeks
Alkylating agent
Oral
Twice daily
PI3K-delta inhibitor
Indications
- Chronic Lymphocytic Leukemia
- Indolent B-Cell Non-Hodgkin Lymphoma
- Chronic Lymphocytic Leukemia
Dosing
Chronic Lymphocytic Leukemia 100 mg/m2 IV over 10 minutes on Days 1 and 2 of a 28-day cycle, up to 6 cycles.
Indolent B-Cell Non-Hodgkin Lymphoma 120 mg/m2 IV over 10 minutes on Days 1 and 2 of a 21-day cycle, up to 8 cycles.
Chronic Lymphocytic Leukemia 150 mg orally twice daily with or without food until disease progression or unacceptable toxicity; dose reductions to 100 mg twice daily apply after interruption for certain adverse reactions.
Contraindications
- Known hypersensitivity (e.g., anaphylactic and anaphylactoid reactions) to bendamustine, polyethylene glycol 400, propylene glycol, or monothioglycerol
- History of serious hypersensitivity reactions to idelalisib, including anaphylaxis
- History of toxic epidermal necrolysis with any drug
Adverse Reactions
Most common (>=30%) Nausea, fatigue, vomiting, diarrhea, pyrexia
Serious Febrile neutropenia, pneumonia, acute renal failure, cardiac failure, hypersensitivity, skin reactions, pulmonary fibrosis, myelodysplastic syndrome
Postmarketing Pancytopenia, atrial fibrillation, congestive heart failure, myocardial infarction, anaphylaxis, progressive multifocal leukoencephalopathy, nephrogenic diabetes insipidus, pneumonitis, DRESS, non-melanoma skin cancer, Stevens-Johnson syndrome, toxic epidermal necrolysis
Most common (>30%) Diarrhea, pneumonia, pyrexia, fatigue, rash, cough, nausea
Serious Hepatotoxicity, severe diarrhea or colitis, pneumonitis, infections (including sepsis, CMV, PJP), intestinal perforation, severe cutaneous reactions, hypersensitivity reactions, neutropenia
Postmarketing Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms
Pharmacology
Bendamustine is a bifunctional mechlorethamine derivative containing a benzimidazole ring that forms electrophilic alkyl groups, which create covalent interstrand DNA crosslinks leading to cell death via multiple pathways; it is active against both quiescent and dividing cells.
PI3K-delta inhibitor; idelalisib blocks BCR, CXCR4, and CXCR5 signaling pathways to induce apoptosis and inhibit proliferation in normal and malignant B-cells, and reduces chemotaxis and adhesion of lymphoma cells.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Bendeka
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
Zydelig
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Bendeka
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Zydelig
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Bendeka
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Zydelig
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Bendeka.
$5/momo
Zydelig Access Connect Copay Coupon CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.