| Chronic Lymphocytic Leukemia
Calquence Tablets vs Copiktra
Side-by-side clinical, coverage, and cost comparison for chronic lymphocytic leukemia.Deep comparison between: Calquence vs Copiktra with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCopiktra has a higher rate of injection site reactions vs Calquence based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Copiktra but not Calquence, including UnitedHealthcare
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Category
Calquence
Copiktra
At A Glance
Oral
Every 12 hours
BTK inhibitor
Oral
Twice daily
PI3K-delta/gamma inhibitor
Indications
- Mantle cell lymphoma
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
Dosing
Mantle cell lymphoma 100 mg orally approximately every 12 hours until disease progression or unacceptable toxicity; swallow tablet whole with or without food (monotherapy or in combination with bendamustine and rituximab).
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 100 mg orally approximately every 12 hours until disease progression or unacceptable toxicity (monotherapy, or in combination with obinutuzumab or venetoclax).
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 25 mg orally twice daily in 28-day cycles; reduce to 15 mg twice daily for toxicity or when co-administered with strong CYP3A4 inhibitors; discontinue if unable to tolerate 15 mg twice daily.
Contraindications
—
—
Adverse Reactions
Most common (>=30%) Upper respiratory tract infection, diarrhea, headache, musculoskeletal pain.
Serious Serious and opportunistic infections, hemorrhage, cytopenias, second primary malignancies, cardiac arrhythmias, hepatotoxicity including drug-induced liver injury.
Postmarketing Ventricular arrhythmias, drug induced liver injury.
Most common (>=20%) Diarrhea or colitis, neutropenia, rash, fatigue, pyrexia, cough, nausea, upper respiratory infection, pneumonia, musculoskeletal pain, anemia
Serious Infection, diarrhea or colitis, pneumonia, rash, pneumonitis
Pharmacology
Acalabrutinib is a small-molecule inhibitor of Bruton tyrosine kinase (BTK); it and its active metabolite ACP-5862 form a covalent bond with a cysteine residue in the BTK active site, inhibiting BTK enzymatic activity and downstream B-cell proliferation, trafficking, chemotaxis, and adhesion pathways required for B-cell malignancy growth.
Duvelisib is a PI3K-delta/gamma inhibitor that blocks B-cell receptor signaling and CXCR12-mediated chemotaxis of malignant B-cells, inducing growth inhibition and reduced viability in CLL tumor cells and malignant B-cell lines.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Calquence
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
Copiktra
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (0/12) · Qty limit (12/12)
UnitedHealthcare
Calquence
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (6/8)
Copiktra
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Calquence
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Copiktra
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Chronic Lymphocytic Leukemia (CLL)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$5/momo
Secura Care Co-Pay Program: CopiktraCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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CalquenceView full Calquence profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.