| Coronary heart disease

Norliqva vs Xarelto

Side-by-side clinical, coverage, and cost comparison for coronary heart disease.

Deep comparison between: Norliqva vs Xarelto with Prescriber.AI

AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.

Safety signalsXarelto has a higher rate of injection site reactions vs Norliqva based on FDA-approved prescribing information

Coverage gaps3 major payers require step therapy for Xarelto but not Norliqva, including UnitedHealthcare

Category

Norliqva

Xarelto

At A Glance

RouteOral

FrequencyDaily

ClassCalcium channel blocker

RouteOral

FrequencyOnce or twice daily

ClassFactor Xa inhibitor

Indications

Hypertensive disease
Stable angina
Coronary heart disease

Atrial Fibrillation
Deep Vein Thrombosis
Pulmonary Embolism
Venous Thrombosis
Coronary heart disease
Peripheral Arterial Diseases

Dosing

Hypertensive disease Adults: 5 mg orally once daily (max 10 mg); small, fragile, elderly, or hepatic insufficiency patients start at 2.5 mg once daily; pediatric patients (>=6 years): 2.5-5 mg orally once daily.

Stable angina 5-10 mg orally once daily; most patients require 10 mg for adequate effect.

Coronary heart disease 5-10 mg orally once daily; majority of patients in clinical studies required 10 mg.

Atrial Fibrillation 20 mg once daily with evening meal (CrCl >50 mL/min); 15 mg once daily with evening meal (CrCl <=50 mL/min), oral.

Deep Vein Thrombosis, Pulmonary Embolism 15 mg twice daily with food for 21 days, then 20 mg once daily with food for remaining treatment, oral.

Venous Thrombosis 10 mg once daily with or without food: for recurrence prevention after at least 6 months of standard anticoagulant treatment; or 35 days post-hip replacement surgery; or 12 days post-knee replacement surgery; or 31-39 days total for prophylaxis in acutely ill medical patients, oral.

Coronary heart disease, Peripheral Arterial Diseases 2.5 mg twice daily with or without food, in combination with aspirin 75-100 mg once daily, oral.

Contraindications

Known sensitivity to amlodipine

Active pathological bleeding
Severe hypersensitivity reaction to rivaroxaban or any excipient (e.g., anaphylactic reactions)

Drug Interactions

1162View drug interactions

1272View drug interactions

Adverse Reactions

Most common (>1%) Edema, dizziness, flushing, palpitation, fatigue, nausea.

Postmarketing Gynecomastia, jaundice, hepatic enzyme elevations, extrapyramidal disorder.

Most common Bleeding complications, wound secretion, pruritus, back pain, abdominal pain, muscle spasm, dizziness, fatigue

Serious Intracranial hemorrhage, gastrointestinal bleeding, fatal bleeding, spinal/epidural hematoma

Postmarketing Agranulocytosis, thrombocytopenia, jaundice, cholestasis, hepatitis, hypersensitivity, anaphylactic reaction, anaphylactic shock, angioedema, hemiparesis, anticoagulant-related nephropathy, eosinophilic pneumonia, Stevens-Johnson syndrome, DRESS, atraumatic splenic rupture

Pharmacology

Amlodipine is a dihydropyridine calcium channel blocker that inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, acting as a peripheral arterial vasodilator to reduce peripheral vascular resistance and blood pressure, and relieving angina by reducing myocardial oxygen demand and blocking coronary vasospasm.

Rivaroxaban is a selective oral Factor Xa (FXa) inhibitor that does not require a cofactor for activity; by inhibiting free FXa and prothrombinase activity, it decreases thrombin generation and indirectly inhibits thrombin-induced platelet aggregation.

View Full FDA Information

View full FDA information

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Most Common Insurance

Anthem BCBS

Norliqva