| Coronary heart disease
Praluent vs Norliqva
Side-by-side clinical, coverage, and cost comparison for coronary heart disease.Deep comparison between: Praluent vs Norliqva with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNorliqva has a higher rate of injection site reactions vs Praluent based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Norliqva but not Praluent, including UnitedHealthcare
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Category
Praluent
Norliqva
At A Glance
SC injection
Every 2-4 weeks
PCSK9 inhibitor
Oral
Daily
Calcium channel blocker
Indications
- Myocardial Infarction
- Coronary heart disease
- Cerebrovascular accident
- Angina, Unstable
- Hypercholesterolemia
- Familial hypercholesterolemia - heterozygous
- Homozygous Familial Hypercholesterolemia
- Hypertensive disease
- Stable angina
- Coronary heart disease
Dosing
Hypercholesterolemia, Myocardial Infarction, Coronary heart disease, Cerebrovascular accident, Angina, Unstable 75 mg SC once every 2 weeks or 300 mg SC once every 4 weeks; may adjust to 150 mg SC every 2 weeks if LDL-C response is inadequate.
Familial hypercholesterolemia - heterozygous (adults on LDL apheresis), Homozygous Familial Hypercholesterolemia 150 mg SC once every 2 weeks; may be administered without regard to timing of LDL apheresis.
Familial hypercholesterolemia - heterozygous (pediatric, <50 kg) 150 mg SC once every 4 weeks; may adjust to 75 mg SC once every 2 weeks if LDL-C response is inadequate.
Familial hypercholesterolemia - heterozygous (pediatric, >=50 kg) 300 mg SC once every 4 weeks; may adjust to 150 mg SC once every 2 weeks if LDL-C response is inadequate.
Hypertensive disease Adults: 5 mg orally once daily (max 10 mg); small, fragile, elderly, or hepatic insufficiency patients start at 2.5 mg once daily; pediatric patients (>=6 years): 2.5-5 mg orally once daily.
Stable angina 5-10 mg orally once daily; most patients require 10 mg for adequate effect.
Coronary heart disease 5-10 mg orally once daily; majority of patients in clinical studies required 10 mg.
Contraindications
- Previous serious hypersensitivity reaction to alirocumab or any excipient in PRALUENT
- Known sensitivity to amlodipine
Adverse Reactions
Most common (>=2%) Injection site reactions, influenza, diarrhea, myalgia, muscle spasms, contusion
Serious Hypersensitivity vasculitis, nummular eczema, angioedema
Postmarketing Angioedema, influenza-like illness
Most common (>1%) Edema, dizziness, flushing, palpitation, fatigue, nausea.
Postmarketing Gynecomastia, jaundice, hepatic enzyme elevations, extrapyramidal disorder.
Pharmacology
Alirocumab is a human monoclonal antibody that inhibits PCSK9, a protein that promotes LDL receptor degradation on hepatocytes, thereby increasing LDL receptor availability and lowering circulating LDL-C levels.
Amlodipine is a dihydropyridine calcium channel blocker that inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, acting as a peripheral arterial vasodilator to reduce peripheral vascular resistance and blood pressure, and relieving angina by reducing myocardial oxygen demand and blocking coronary vasospasm.
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Most Common Insurance
Anthem BCBS
Praluent
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (9/12)
Norliqva
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (6/12)
UnitedHealthcare
Praluent
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (1/8) · Qty limit (1/8)
Norliqva
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Praluent
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (2/3)
Norliqva
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$50/momo
MyPraluent Copay CardCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Norliqva.
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PraluentView full Praluent profile
NorliqvaView full Norliqva profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.