| Cystic Fibrosis
Alyftrek vs Kalydeco
Side-by-side clinical, coverage, and cost comparison for cystic fibrosis.Deep comparison between: Alyftrek vs Kalydeco with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsKalydeco has a higher rate of injection site reactions vs Alyftrek based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Kalydeco but not Alyftrek, including UnitedHealthcare
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Category
Alyftrek
Kalydeco
At A Glance
Oral
Once daily
CFTR modulator (corrector/potentiator)
Oral
Every 12 hours
CFTR potentiator
Indications
- Cystic Fibrosis
- Cystic Fibrosis
Dosing
Cystic Fibrosis (ages 6 to <12, weight <40 kg) Three tablets of vanzacaftor 4 mg/tezacaftor 20 mg/deutivacaftor 50 mg once daily orally with fat-containing food.
Cystic Fibrosis (ages 6 to <12, weight >=40 kg; ages >=12) Two tablets of vanzacaftor 10 mg/tezacaftor 50 mg/deutivacaftor 125 mg once daily orally with fat-containing food.
Cystic Fibrosis Weight-based dosing every 12 hours with fat-containing food: oral granules from 5.8 mg (1 to <2 months, >=3 kg) up to 75 mg (6 months to <6 years, >=14 kg); 150 mg tablet for patients >=6 years; dose reduced to once daily for moderate hepatic impairment or concomitant moderate CYP3A inhibitors (>=6 months), and to twice weekly for strong CYP3A inhibitors (>=6 months).
Contraindications
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Adverse Reactions
Most common (>=5%) Cough, nasopharyngitis, upper respiratory tract infection, headache, oropharyngeal pain, influenza, fatigue, ALT increased, rash, AST increased, sinus congestion
Serious Drug-induced liver injury and liver failure, hypersensitivity reactions including anaphylaxis, intracranial hypertension, neuropsychiatric events including suicidal thoughts and behaviors, cataracts
Postmarketing Intracranial hypertension, anxiety, depression, suicidal ideation and behavior, insomnia
Most common (>=8%) Headache, oropharyngeal pain, upper respiratory tract infection, nasal congestion, abdominal pain, nasopharyngitis, diarrhea, rash, nausea, dizziness
Serious Abdominal pain, increased hepatic enzymes, hypoglycemia, transaminase elevations
Postmarketing Anaphylaxis, intracranial hypertension, anxiety, depression, suicidal ideation and behavior, insomnia
Pharmacology
Vanzacaftor and tezacaftor are CFTR correctors that bind to different sites on the CFTR protein to facilitate cellular processing and trafficking of mutant CFTR (including F508del) to the cell surface; deutivacaftor is a CFTR potentiator that enhances channel open probability at the cell surface, resulting in increased CFTR quantity and function.
Ivacaftor is a CFTR potentiator that facilitates increased chloride transport by potentiating the channel open probability (gating) of CFTR protein located at the epithelial cell surface; clinical benefit requires at least one ivacaftor-responsive CFTR mutation identified by clinical and/or in vitro assay data.
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Most Common Insurance
Anthem BCBS
Alyftrek
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Kalydeco
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (11/12)
UnitedHealthcare
Alyftrek
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (4/8) · Qty limit (0/8)
Kalydeco
- Covered on 4 commercial plans
- PA (6/8) · Step Therapy (0/8) · Qty limit (1/8)
Humana
Alyftrek
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (2/3)
Kalydeco
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Cystic Fibrosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Cystic Fibrosis
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.