| Diabetes Mellitus
Apidra vs Lantus
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Apidra vs Lantus Solostar with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLantus Solostar has a higher rate of injection site reactions vs Apidra based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lantus Solostar but not Apidra, including UnitedHealthcare
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Category
Apidra
Lantus Solostar
At A Glance
SC injection
With meals
Rapid-acting insulin analog
SC injection
Once daily
Long-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject SC within 15 minutes before a meal or within 20 minutes after starting a meal into the abdomen, thigh, or upper arm; generally use with an intermediate or long-acting insulin.
Continuous Subcutaneous Infusion (Insulin Pump) Administer by CSII using an insulin pump per manufacturer instructions; change reservoir at least every 48 hours; do not dilute or mix with other insulins in the pump.
Intravenous Administration Administer only under medical supervision; dilute to 0.05-1 unit/mL in 0.9% sodium chloride injection using polyvinyl chloride infusion bags.
Diabetes Mellitus, Type 1 Approximately one-third of total daily insulin requirements SC once daily at the same time each day; use short-acting, premeal insulin to satisfy the remainder.
Diabetes Mellitus, Type 2 0.2 units/kg or up to 10 units SC once daily for insulin-naive patients; adjust based on metabolic needs and glucose monitoring results.
Contraindications
- During episodes of hypoglycemia
- Known hypersensitivity to insulin glulisine or any of the excipients in APIDRA
- During episodes of hypoglycemia
- Hypersensitivity to insulin glargine or any excipient in LANTUS
Adverse Reactions
Most common (>=5%) Nasopharyngitis, hypoglycemia, upper respiratory tract infection, influenza, peripheral edema, arthralgia, headache
Serious Severe hypoglycemia, anaphylaxis and generalized allergic reactions, hypokalemia, lipodystrophy, worsening of diabetic retinopathy, acute painful peripheral neuropathy
Postmarketing Medication errors with long-acting insulins, localized cutaneous amyloidosis, hyperglycemia and hypoglycemia associated with injection into amyloidosis sites
Most common (>=5%) Upper respiratory tract infection, infection (body system unspecified), accidental injury, headache, peripheral edema, retinal vascular disorder, injection site reactions (redness, pain, itching, urticaria, edema, inflammation)
Serious Severe hypoglycemia, systemic hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, hypotension, shock), hypokalemia, lipodystrophy, weight gain
Postmarketing Medication errors with rapid-acting insulins accidentally administered instead of LANTUS, localized cutaneous amyloidosis at injection site
Pharmacology
Rapid-acting human insulin analog; lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, with more rapid onset and shorter duration of activity than regular human insulin when given subcutaneously.
Insulin glargine is a long-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, providing a relatively constant concentration/time profile over 24 hours with no pronounced peak after subcutaneous injection.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Apidra
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Lantus Solostar
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (6/12) · Qty limit (0/12)
UnitedHealthcare
Apidra
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Lantus Solostar
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Apidra
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (3/3) · Qty limit (0/3)
Lantus Solostar
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Apidra.
No savings programs available for Lantus Solostar.
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ApidraView full Apidra profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.