| Diabetes Mellitus
Humulin R U-500 vs Humalog
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Humulin vs Sterile Diluent with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSterile Diluent has a higher rate of injection site reactions vs Humulin based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sterile Diluent but not Humulin, including UnitedHealthcare
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Category
Humulin
Sterile Diluent
At A Glance
SC injection
2-3 times daily
Human insulin
SC injection
With meals
Rapid-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus SC injection 2-3 times daily approximately 30 minutes before meals; individualize dose based on metabolic needs, blood glucose monitoring results, and glycemic control goal; do not mix with other insulins or administer IV.
Diabetes Mellitus Administer subcutaneously within 15 minutes before or immediately after a meal into the abdominal wall, thigh, upper arm, or buttocks; HUMALOG U-100 may also be administered by continuous subcutaneous infusion via insulin pump or by intravenous infusion (diluted, under medical supervision); dosage must be individualized based on route, metabolic needs, and blood glucose monitoring results.
Contraindications
- Active episodes of hypoglycemia
- Hypersensitivity to HUMULIN R U-500 or any of its excipients
- Episodes of hypoglycemia
- Hypersensitivity to insulin lispro or any excipient in HUMALOG
Adverse Reactions
Most common Hypoglycemia
Serious Severe allergic reactions including anaphylaxis, angioedema, bronchospasm, hypotension, shock; hypokalemia
Postmarketing Lipodystrophy, localized cutaneous amyloidosis, injection site reactions, weight gain, peripheral edema, anti-insulin antibodies
Most common (>=5%) Flu syndrome, pharyngitis, rhinitis, headache, pain, increased cough, infection, nausea
Serious Hypoglycemia, hypersensitivity reactions (including anaphylaxis), hypokalemia, lipodystrophy, peripheral edema
Postmarketing Localized cutaneous amyloidosis at injection site, insulin substitution medication errors, hyperglycemia or hypoglycemia associated with injecting into areas of cutaneous amyloidosis
Pharmacology
Human insulin; lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, and also inhibits lipolysis and proteolysis while enhancing protein synthesis.
Insulin lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat and inhibiting hepatic glucose production; it is equipotent to human insulin on a molar basis but has a more rapid onset and shorter duration of action.
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Most Common Insurance
Anthem BCBS
Humulin
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (0/12)
Sterile Diluent
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (8/12)
UnitedHealthcare
Humulin
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (6/8)
Sterile Diluent
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Humulin
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Sterile Diluent
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Humulin.
No savings programs available for Sterile Diluent.
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HumulinView full Humulin profile
Sterile DiluentView full Sterile Diluent profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.