| Diabetes Mellitus
Humulin R U-500 vs Toujeo
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Humulin vs Toujeo with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsToujeo has a higher rate of injection site reactions vs Humulin based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Toujeo but not Humulin, including UnitedHealthcare
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Category
Humulin
Toujeo
At A Glance
SC injection
2-3 times daily
Human insulin
SC injection
Once daily
Long-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus SC injection 2-3 times daily approximately 30 minutes before meals; individualize dose based on metabolic needs, blood glucose monitoring results, and glycemic control goal; do not mix with other insulins or administer IV.
Diabetes Mellitus, Type 1 (insulin-naive) Approximately one-third to one-half of total daily insulin dose SC once daily; remainder given as short-acting insulin divided between daily meals.
Diabetes Mellitus, Type 2 (insulin-naive) 0.2 units/kg SC once daily.
Switching from once-daily long/intermediate-acting insulin Start at same unit dose as prior once-daily long-acting insulin SC once daily; monitor glucose closely during initial weeks.
Switching from twice-daily long/intermediate-acting insulin Start at 80% of total daily NPH or insulin detemir twice-daily dosage SC once daily; monitor glucose frequently.
Contraindications
- Active episodes of hypoglycemia
- Hypersensitivity to HUMULIN R U-500 or any of its excipients
- Active hypoglycemia episode
- Hypersensitivity to insulin glargine or any excipient in Toujeo
Adverse Reactions
Most common Hypoglycemia
Serious Severe allergic reactions including anaphylaxis, angioedema, bronchospasm, hypotension, shock; hypokalemia
Postmarketing Lipodystrophy, localized cutaneous amyloidosis, injection site reactions, weight gain, peripheral edema, anti-insulin antibodies
Most common (>=5%) nasopharyngitis, upper respiratory tract infection, hypoglycemia
Serious severe hypoglycemia, anaphylaxis, peripheral edema, lipodystrophy, hypokalemia
Postmarketing localized cutaneous amyloidosis at injection site, hyperglycemia or hypoglycemia associated with injections into or away from amyloidosis areas
Pharmacology
Human insulin; lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, and also inhibits lipolysis and proteolysis while enhancing protein synthesis.
Long-acting insulin analog; regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat, inhibiting hepatic glucose production, inhibiting lipolysis and proteolysis, and enhancing protein synthesis.
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Most Common Insurance
Anthem BCBS
Humulin
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (0/12)
Toujeo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
UnitedHealthcare
Humulin
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (6/8)
Toujeo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Humana
Humulin
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Toujeo
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Humulin.
No savings programs available for Toujeo.
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HumulinView full Humulin profile
ToujeoView full Toujeo profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.