| Diabetes Mellitus
Lantus vs Levemir
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Lantus Solostar vs Levemir with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLevemir has a higher rate of injection site reactions vs Lantus Solostar based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Levemir but not Lantus Solostar, including UnitedHealthcare
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Category
Lantus Solostar
Levemir
At A Glance
SC injection
Once daily
Long-acting insulin analog
SC injection
Once or twice daily
Long-acting basal insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus, Type 1 Approximately one-third of total daily insulin requirements SC once daily at the same time each day; use short-acting, premeal insulin to satisfy the remainder.
Diabetes Mellitus, Type 2 0.2 units/kg or up to 10 units SC once daily for insulin-naive patients; adjust based on metabolic needs and glucose monitoring results.
Diabetes Mellitus (Type 1) Approximately one-third to one-half of the total daily insulin dose SC once or twice daily in combination with rapid-acting or short-acting insulin; initial total daily dose 0.2-0.4 units/kg in insulin-naive patients.
Diabetes Mellitus (Type 2) 10 units (or 0.1-0.2 units/kg) SC once daily in the evening or divided into a twice-daily regimen in patients inadequately controlled on oral antidiabetic medications or a GLP-1 receptor agonist.
Contraindications
- During episodes of hypoglycemia
- Hypersensitivity to insulin glargine or any excipient in LANTUS
- Episodes of hypoglycemia
- Hypersensitivity to insulin detemir or any excipient in LEVEMIR, including reactions such as anaphylaxis
Adverse Reactions
Most common (>=5%) Upper respiratory tract infection, infection (body system unspecified), accidental injury, headache, peripheral edema, retinal vascular disorder, injection site reactions (redness, pain, itching, urticaria, edema, inflammation)
Serious Severe hypoglycemia, systemic hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, hypotension, shock), hypokalemia, lipodystrophy, weight gain
Postmarketing Medication errors with rapid-acting insulins accidentally administered instead of LANTUS, localized cutaneous amyloidosis at injection site
Most common (>=5%) Upper respiratory tract infection, headache, pharyngitis, influenza-like illness, abdominal pain, hypoglycemia
Serious Severe hypoglycemia, anaphylaxis, generalized skin reactions, angioedema, bronchospasm, hypotension, shock, lipodystrophy, peripheral edema, hypokalemia
Postmarketing Medication errors with accidental administration of other insulins instead of LEVEMIR, localized cutaneous amyloidosis, hyperglycemia or hypoglycemia associated with injection into amyloidosis sites
Pharmacology
Insulin glargine is a long-acting human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, providing a relatively constant concentration/time profile over 24 hours with no pronounced peak after subcutaneous injection.
Long-acting basal human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; prolonged duration of action is mediated by self-association of drug molecules at the injection site and albumin binding in the bloodstream.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Lantus Solostar
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (6/12) · Qty limit (0/12)
Levemir
- Covered on 5 commercial plans
- PA (7/12) · Step Therapy (1/12) · Qty limit (0/12)
UnitedHealthcare
Lantus Solostar
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Levemir
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Lantus Solostar
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Levemir
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Lantus Solostar.
No savings programs available for Levemir.
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Lantus SolostarView full Lantus Solostar profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.