| Diabetes Mellitus
Levemir vs Humalog
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Levemir vs Sterile Diluent with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSterile Diluent has a higher rate of injection site reactions vs Levemir based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sterile Diluent but not Levemir, including UnitedHealthcare
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Category
Levemir
Sterile Diluent
At A Glance
SC injection
Once or twice daily
Long-acting basal insulin analog
SC injection
With meals
Rapid-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus (Type 1) Approximately one-third to one-half of the total daily insulin dose SC once or twice daily in combination with rapid-acting or short-acting insulin; initial total daily dose 0.2-0.4 units/kg in insulin-naive patients.
Diabetes Mellitus (Type 2) 10 units (or 0.1-0.2 units/kg) SC once daily in the evening or divided into a twice-daily regimen in patients inadequately controlled on oral antidiabetic medications or a GLP-1 receptor agonist.
Diabetes Mellitus Administer subcutaneously within 15 minutes before or immediately after a meal into the abdominal wall, thigh, upper arm, or buttocks; HUMALOG U-100 may also be administered by continuous subcutaneous infusion via insulin pump or by intravenous infusion (diluted, under medical supervision); dosage must be individualized based on route, metabolic needs, and blood glucose monitoring results.
Contraindications
- Episodes of hypoglycemia
- Hypersensitivity to insulin detemir or any excipient in LEVEMIR, including reactions such as anaphylaxis
- Episodes of hypoglycemia
- Hypersensitivity to insulin lispro or any excipient in HUMALOG
Adverse Reactions
Most common (>=5%) Upper respiratory tract infection, headache, pharyngitis, influenza-like illness, abdominal pain, hypoglycemia
Serious Severe hypoglycemia, anaphylaxis, generalized skin reactions, angioedema, bronchospasm, hypotension, shock, lipodystrophy, peripheral edema, hypokalemia
Postmarketing Medication errors with accidental administration of other insulins instead of LEVEMIR, localized cutaneous amyloidosis, hyperglycemia or hypoglycemia associated with injection into amyloidosis sites
Most common (>=5%) Flu syndrome, pharyngitis, rhinitis, headache, pain, increased cough, infection, nausea
Serious Hypoglycemia, hypersensitivity reactions (including anaphylaxis), hypokalemia, lipodystrophy, peripheral edema
Postmarketing Localized cutaneous amyloidosis at injection site, insulin substitution medication errors, hyperglycemia or hypoglycemia associated with injecting into areas of cutaneous amyloidosis
Pharmacology
Long-acting basal human insulin analog that regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; prolonged duration of action is mediated by self-association of drug molecules at the injection site and albumin binding in the bloodstream.
Insulin lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat and inhibiting hepatic glucose production; it is equipotent to human insulin on a molar basis but has a more rapid onset and shorter duration of action.
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Most Common Insurance
Anthem BCBS
Levemir
- Covered on 5 commercial plans
- PA (7/12) · Step Therapy (1/12) · Qty limit (0/12)
Sterile Diluent
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (8/12)
UnitedHealthcare
Levemir
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Sterile Diluent
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Levemir
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (1/3) · Qty limit (0/3)
Sterile Diluent
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Levemir.
No savings programs available for Sterile Diluent.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.