| Diabetes Mellitus
Novolog 70/30 vs Humalog
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Novolog Mix 70/30 vs Sterile Diluent with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSterile Diluent has a higher rate of injection site reactions vs Novolog Mix 70/30 based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sterile Diluent but not Novolog Mix 70/30, including UnitedHealthcare
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Category
Novolog Mix 70/30
Sterile Diluent
At A Glance
SC injection
Twice daily
Insulin analog
SC injection
With meals
Rapid-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject subcutaneously in the abdominal region, buttocks, thigh, or upper arm twice daily within 15 minutes before meal initiation (or after meal initiation for type 2 patients); individualize dose based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Diabetes Mellitus Administer subcutaneously within 15 minutes before or immediately after a meal into the abdominal wall, thigh, upper arm, or buttocks; HUMALOG U-100 may also be administered by continuous subcutaneous infusion via insulin pump or by intravenous infusion (diluted, under medical supervision); dosage must be individualized based on route, metabolic needs, and blood glucose monitoring results.
Contraindications
- Episodes of hypoglycemia
- Hypersensitivity to Novolog Mix 70/30 or one of its excipients
- Episodes of hypoglycemia
- Hypersensitivity to insulin lispro or any excipient in HUMALOG
Adverse Reactions
Most common (>=5%) Hypoglycemia, headache, influenza-like symptoms, dyspepsia, back pain, diarrhea, pharyngitis, rhinitis, skeletal pain, upper respiratory tract infection, neuropathy, abdominal pain
Serious Severe hypoglycemia requiring assistance or parenteral glucose/glucagon, anaphylaxis, lipodystrophy, localized cutaneous amyloidosis
Postmarketing Localized cutaneous amyloidosis at injection site, hyperglycemia with repeated injections into areas of amyloidosis, hypoglycemia with sudden change to unaffected injection site, medication errors due to accidental substitution
Most common (>=5%) Flu syndrome, pharyngitis, rhinitis, headache, pain, increased cough, infection, nausea
Serious Hypoglycemia, hypersensitivity reactions (including anaphylaxis), hypokalemia, lipodystrophy, peripheral edema
Postmarketing Localized cutaneous amyloidosis at injection site, insulin substitution medication errors, hyperglycemia or hypoglycemia associated with injecting into areas of cutaneous amyloidosis
Pharmacology
Biphasic insulin analog consisting of 70% insulin aspart protamine (prolonged absorption) and 30% soluble insulin aspart (rapid absorption); lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and by inhibiting hepatic glucose production.
Insulin lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat and inhibiting hepatic glucose production; it is equipotent to human insulin on a molar basis but has a more rapid onset and shorter duration of action.
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Most Common Insurance
Anthem BCBS
Novolog Mix 70/30
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
Sterile Diluent
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (8/12)
UnitedHealthcare
Novolog Mix 70/30
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Sterile Diluent
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Novolog Mix 70/30
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Sterile Diluent
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Novolog Mix 70/30.
No savings programs available for Sterile Diluent.
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Novolog Mix 70/30View full Novolog Mix 70/30 profile
Sterile DiluentView full Sterile Diluent profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.