| Diabetes Mellitus
Novolog 70/30 vs Tresiba
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Novolog Mix 70/30 vs Tresiba with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTresiba has a higher rate of injection site reactions vs Novolog Mix 70/30 based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tresiba but not Novolog Mix 70/30, including UnitedHealthcare
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Category
Novolog Mix 70/30
Tresiba
At A Glance
SC injection
Twice daily
Insulin analog
SC injection
Once daily
Long-acting basal insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus Inject subcutaneously in the abdominal region, buttocks, thigh, or upper arm twice daily within 15 minutes before meal initiation (or after meal initiation for type 2 patients); individualize dose based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
Diabetes Mellitus, Type 1 SC once daily; starting dose for insulin-naive adults approximately one-third to one-half of total daily insulin dose with remainder as short-acting insulin divided among meals; when switching, adults start at same unit dose as total daily long/intermediate-acting insulin, pediatric patients (1 year and older) start at 80% of that dose.
Diabetes Mellitus, Type 2 SC once daily; starting dose 10 units for insulin-naive adults; when switching, start at same unit dose as total daily long/intermediate-acting insulin.
Contraindications
- Episodes of hypoglycemia
- Hypersensitivity to Novolog Mix 70/30 or one of its excipients
- Episodes of hypoglycemia
- Hypersensitivity to insulin degludec or any excipient in TRESIBA
Adverse Reactions
Most common (>=5%) Hypoglycemia, headache, influenza-like symptoms, dyspepsia, back pain, diarrhea, pharyngitis, rhinitis, skeletal pain, upper respiratory tract infection, neuropathy, abdominal pain
Serious Severe hypoglycemia requiring assistance or parenteral glucose/glucagon, anaphylaxis, lipodystrophy, localized cutaneous amyloidosis
Postmarketing Localized cutaneous amyloidosis at injection site, hyperglycemia with repeated injections into areas of amyloidosis, hypoglycemia with sudden change to unaffected injection site, medication errors due to accidental substitution
Most common (>=5%) Nasopharyngitis, upper respiratory tract infection, headache, sinusitis, gastroenteritis, diarrhea
Serious Hypoglycemia, hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, hypotension, shock), hypokalemia
Postmarketing Localized cutaneous amyloidosis at injection site, hyperglycemia or hypoglycemia with repeated injections into amyloidosis-affected areas
Pharmacology
Biphasic insulin analog consisting of 70% insulin aspart protamine (prolonged absorption) and 30% soluble insulin aspart (rapid absorption); lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and by inhibiting hepatic glucose production.
Long-acting basal insulin analog that lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; TRESIBA forms multi-hexamers after SC injection creating a subcutaneous depot, with protracted action due to delayed absorption from subcutaneous tissue and binding to circulating albumin.
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Most Common Insurance
Anthem BCBS
Novolog Mix 70/30
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (5/12) · Qty limit (0/12)
Tresiba
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (1/12) · Qty limit (9/12)
UnitedHealthcare
Novolog Mix 70/30
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Tresiba
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Novolog Mix 70/30
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Tresiba
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Novolog Mix 70/30.
No savings programs available for Tresiba.
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Novolog Mix 70/30View full Novolog Mix 70/30 profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.