| Diabetes Mellitus
Rezgovlar vs Humulin R U-500
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Rezvoglar vs Humulin with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsHumulin has a higher rate of injection site reactions vs Rezvoglar based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Humulin but not Rezvoglar, including UnitedHealthcare
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Category
Rezvoglar
Humulin
At A Glance
SC injection
Once daily
Long-acting insulin analog
SC injection
2-3 times daily
Human insulin
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus, Type 1 Approximately one-third of total daily insulin requirements SC once daily at the same time every day; use short-acting premeal insulin for the remainder.
Diabetes Mellitus, Type 2 0.2 units/kg or up to 10 units SC once daily in insulin-naive patients, adjusted based on metabolic needs and blood glucose monitoring results.
Diabetes Mellitus SC injection 2-3 times daily approximately 30 minutes before meals; individualize dose based on metabolic needs, blood glucose monitoring results, and glycemic control goal; do not mix with other insulins or administer IV.
Contraindications
- Episodes of hypoglycemia
- Hypersensitivity to insulin glargine products or any excipient in REZVOGLAR
- Active episodes of hypoglycemia
- Hypersensitivity to HUMULIN R U-500 or any of its excipients
Adverse Reactions
Most common (>=5%) Upper respiratory tract infection, infection, accidental injury, headache, retinal vascular disorder
Serious Severe hypoglycemia, anaphylaxis, angioedema, bronchospasm, hypotension, shock, hypokalemia, lipodystrophy
Postmarketing Localized cutaneous amyloidosis, medication errors with inadvertent insulin substitution, hyperglycemia or hypoglycemia related to injections into amyloidosis-affected sites
Most common Hypoglycemia
Serious Severe allergic reactions including anaphylaxis, angioedema, bronchospasm, hypotension, shock; hypokalemia
Postmarketing Lipodystrophy, localized cutaneous amyloidosis, injection site reactions, weight gain, peripheral edema, anti-insulin antibodies
Pharmacology
Long-acting human insulin analog; regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, lipolysis, and proteolysis while enhancing protein synthesis.
Human insulin; lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production, and also inhibits lipolysis and proteolysis while enhancing protein synthesis.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Rezvoglar
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
Humulin
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (1/12) · Qty limit (0/12)
UnitedHealthcare
Rezvoglar
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (2/8)
Humulin
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (6/8)
Humana
Rezvoglar
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Humulin
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Rezvoglar.
No savings programs available for Humulin.
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RezvoglarView full Rezvoglar profile
HumulinView full Humulin profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.