| Diabetes Mellitus
Toujeo vs Tresiba
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Toujeo vs Tresiba with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsTresiba has a higher rate of injection site reactions vs Toujeo based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Tresiba but not Toujeo, including UnitedHealthcare
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Category
Toujeo
Tresiba
At A Glance
SC injection
Once daily
Long-acting insulin analog
SC injection
Once daily
Long-acting basal insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus, Type 1 (insulin-naive) Approximately one-third to one-half of total daily insulin dose SC once daily; remainder given as short-acting insulin divided between daily meals.
Diabetes Mellitus, Type 2 (insulin-naive) 0.2 units/kg SC once daily.
Switching from once-daily long/intermediate-acting insulin Start at same unit dose as prior once-daily long-acting insulin SC once daily; monitor glucose closely during initial weeks.
Switching from twice-daily long/intermediate-acting insulin Start at 80% of total daily NPH or insulin detemir twice-daily dosage SC once daily; monitor glucose frequently.
Diabetes Mellitus, Type 1 SC once daily; starting dose for insulin-naive adults approximately one-third to one-half of total daily insulin dose with remainder as short-acting insulin divided among meals; when switching, adults start at same unit dose as total daily long/intermediate-acting insulin, pediatric patients (1 year and older) start at 80% of that dose.
Diabetes Mellitus, Type 2 SC once daily; starting dose 10 units for insulin-naive adults; when switching, start at same unit dose as total daily long/intermediate-acting insulin.
Contraindications
- Active hypoglycemia episode
- Hypersensitivity to insulin glargine or any excipient in Toujeo
- Episodes of hypoglycemia
- Hypersensitivity to insulin degludec or any excipient in TRESIBA
Adverse Reactions
Most common (>=5%) nasopharyngitis, upper respiratory tract infection, hypoglycemia
Serious severe hypoglycemia, anaphylaxis, peripheral edema, lipodystrophy, hypokalemia
Postmarketing localized cutaneous amyloidosis at injection site, hyperglycemia or hypoglycemia associated with injections into or away from amyloidosis areas
Most common (>=5%) Nasopharyngitis, upper respiratory tract infection, headache, sinusitis, gastroenteritis, diarrhea
Serious Hypoglycemia, hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, hypotension, shock), hypokalemia
Postmarketing Localized cutaneous amyloidosis at injection site, hyperglycemia or hypoglycemia with repeated injections into amyloidosis-affected areas
Pharmacology
Long-acting insulin analog; regulates glucose metabolism by stimulating peripheral glucose uptake in skeletal muscle and fat, inhibiting hepatic glucose production, inhibiting lipolysis and proteolysis, and enhancing protein synthesis.
Long-acting basal insulin analog that lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; TRESIBA forms multi-hexamers after SC injection creating a subcutaneous depot, with protracted action due to delayed absorption from subcutaneous tissue and binding to circulating albumin.
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Most Common Insurance
Anthem BCBS
Toujeo
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
Tresiba
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (1/12) · Qty limit (9/12)
UnitedHealthcare
Toujeo
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (1/8) · Qty limit (0/8)
Tresiba
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Toujeo
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (0/3)
Tresiba
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Toujeo.
No savings programs available for Tresiba.
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ToujeoView full Toujeo profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.