| Diabetes Mellitus
Tresiba vs Humalog
Side-by-side clinical, coverage, and cost comparison for diabetes mellitus.Deep comparison between: Tresiba vs Sterile Diluent with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsSterile Diluent has a higher rate of injection site reactions vs Tresiba based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Sterile Diluent but not Tresiba, including UnitedHealthcare
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Category
Tresiba
Sterile Diluent
At A Glance
SC injection
Once daily
Long-acting basal insulin analog
SC injection
With meals
Rapid-acting insulin analog
Indications
- Diabetes Mellitus
- Diabetes Mellitus
Dosing
Diabetes Mellitus, Type 1 SC once daily; starting dose for insulin-naive adults approximately one-third to one-half of total daily insulin dose with remainder as short-acting insulin divided among meals; when switching, adults start at same unit dose as total daily long/intermediate-acting insulin, pediatric patients (1 year and older) start at 80% of that dose.
Diabetes Mellitus, Type 2 SC once daily; starting dose 10 units for insulin-naive adults; when switching, start at same unit dose as total daily long/intermediate-acting insulin.
Diabetes Mellitus Administer subcutaneously within 15 minutes before or immediately after a meal into the abdominal wall, thigh, upper arm, or buttocks; HUMALOG U-100 may also be administered by continuous subcutaneous infusion via insulin pump or by intravenous infusion (diluted, under medical supervision); dosage must be individualized based on route, metabolic needs, and blood glucose monitoring results.
Contraindications
- Episodes of hypoglycemia
- Hypersensitivity to insulin degludec or any excipient in TRESIBA
- Episodes of hypoglycemia
- Hypersensitivity to insulin lispro or any excipient in HUMALOG
Adverse Reactions
Most common (>=5%) Nasopharyngitis, upper respiratory tract infection, headache, sinusitis, gastroenteritis, diarrhea
Serious Hypoglycemia, hypersensitivity reactions (anaphylaxis, angioedema, bronchospasm, hypotension, shock), hypokalemia
Postmarketing Localized cutaneous amyloidosis at injection site, hyperglycemia or hypoglycemia with repeated injections into amyloidosis-affected areas
Most common (>=5%) Flu syndrome, pharyngitis, rhinitis, headache, pain, increased cough, infection, nausea
Serious Hypoglycemia, hypersensitivity reactions (including anaphylaxis), hypokalemia, lipodystrophy, peripheral edema
Postmarketing Localized cutaneous amyloidosis at injection site, insulin substitution medication errors, hyperglycemia or hypoglycemia associated with injecting into areas of cutaneous amyloidosis
Pharmacology
Long-acting basal insulin analog that lowers blood glucose by stimulating peripheral glucose uptake in skeletal muscle and fat and inhibiting hepatic glucose production; TRESIBA forms multi-hexamers after SC injection creating a subcutaneous depot, with protracted action due to delayed absorption from subcutaneous tissue and binding to circulating albumin.
Insulin lispro is a rapid-acting human insulin analog that lowers blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat and inhibiting hepatic glucose production; it is equipotent to human insulin on a molar basis but has a more rapid onset and shorter duration of action.
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Most Common Insurance
Anthem BCBS
Tresiba
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (1/12) · Qty limit (9/12)
Sterile Diluent
- Covered on 5 commercial plans
- PA (0/12) · Step Therapy (0/12) · Qty limit (8/12)
UnitedHealthcare
Tresiba
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Sterile Diluent
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Tresiba
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (0/3)
Sterile Diluent
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Tresiba.
No savings programs available for Sterile Diluent.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.