| Diabetic Retinopathy
Eylea HD vs Cimerli
Side-by-side clinical, coverage, and cost comparison for diabetic retinopathy.Deep comparison between: Eylea Hd vs Cimerli with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCimerli has a higher rate of injection site reactions vs Eylea Hd based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cimerli but not Eylea Hd, including UnitedHealthcare
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Category
Eylea Hd
Cimerli
At A Glance
Intravitreal injection
Every 8-16 weeks
VEGF-A/PlGF inhibitor
Intravitreal injection
Monthly
VEGF-A antagonist
Indications
- Age related macular degeneration
- Macular edema due to diabetes mellitus
- Diabetic Retinopathy
- Retinal Vein Occlusion
- Exudative age-related macular degeneration
- Retinal Vein Occlusion
- Macular edema due to diabetes mellitus
- Diabetic Retinopathy
- Myopic choroidal neovascularization
Dosing
Age related macular degeneration, Macular edema due to diabetes mellitus 8 mg (0.07 mL) intravitreal injection every 4 weeks for 3 doses, then once every 8 to 16 weeks (+/- 1 week); extended dosing once every 20 weeks (+/- 1 week) may be considered after 1 year of successful response.
Diabetic Retinopathy 8 mg (0.07 mL) intravitreal injection every 4 weeks for 3 doses, then once every 8 to 12 weeks (+/- 1 week).
Retinal Vein Occlusion 8 mg (0.07 mL) intravitreal injection every 4 weeks for 3 to 5 doses, then once every 8 weeks (+/- 1 week).
Exudative age-related macular degeneration 0.5 mg (0.05 mL) by intravitreal injection once monthly (approximately 28 days); alternatively, 3 monthly doses followed by less frequent dosing, or one dose every 3 months after 4 monthly doses, with regular assessment.
Retinal Vein Occlusion 0.5 mg (0.05 mL) by intravitreal injection once monthly (approximately 28 days).
Macular edema due to diabetes mellitus, Diabetic Retinopathy 0.3 mg (0.05 mL) by intravitreal injection once monthly (approximately 28 days).
Myopic choroidal neovascularization 0.5 mg (0.05 mL) by intravitreal injection once monthly (approximately 28 days) for up to 3 months; may be retreated if needed.
Contraindications
- Ocular or periocular infections
- Active intraocular inflammation
- Known hypersensitivity to aflibercept or any excipient in EYLEA HD
- Ocular or periocular infections
- Known hypersensitivity to ranibizumab products or any excipient in CIMERLI
Adverse Reactions
Most common (>=3%) Cataract, conjunctival hemorrhage, corneal epithelium defect, intraocular pressure increased, ocular discomfort/eye pain/eye irritation, retinal hemorrhage, vision blurred, vitreous detachment, vitreous floaters
Serious Endophthalmitis, retinal detachments, retinal vasculitis with or without occlusion, increase in intraocular pressure, thromboembolic events
Postmarketing Retinal vasculitis, occlusive retinal vasculitis, scleritis
Most common Conjunctival hemorrhage, eye pain, vitreous floaters, increased intraocular pressure, vitreous detachment, cataract, nasopharyngitis, anemia, nausea, cough
Serious Endophthalmitis, retinal detachment, increased intraocular pressure, thromboembolic events, rhegmatogenous retinal detachment, iatrogenic traumatic cataract
Postmarketing Tear of retinal pigment epithelium (patients with neovascular AMD)
Pharmacology
Aflibercept acts as a soluble decoy receptor that binds VEGF-A and PlGF, inhibiting their binding and activation of VEGFR-1 and VEGFR-2, thereby suppressing neovascularization and vascular permeability in the eye.
Ranibizumab-eqrn is a recombinant humanized IgG1 kappa monoclonal antibody fragment that binds to active forms of VEGF-A, preventing interaction with VEGFR1 and VEGFR2 on endothelial cells, thereby reducing endothelial cell proliferation, vascular leakage, and new blood vessel formation in ocular conditions.
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Most Common Insurance
Anthem BCBS
Eylea Hd
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
Cimerli
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (0/12)
UnitedHealthcare
Eylea Hd
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Cimerli
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Eylea Hd
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Cimerli
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Inherited Retinal Diseases - Public Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableGood Days: Macular Disease
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Eylea HdView full Eylea Hd profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.