| Epidermolysis Bullosa Dystrophica
Filsuvez vs Vyjuvek
Side-by-side clinical, coverage, and cost comparison for epidermolysis bullosa dystrophica.Deep comparison between: Filsuvez vs Vyjuvek with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVyjuvek has a higher rate of injection site reactions vs Filsuvez based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vyjuvek but not Filsuvez, including UnitedHealthcare
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Category
Filsuvez
Vyjuvek
At A Glance
Topical
Every 1-4 days
Topical
Once weekly
HSV-1 vector-based gene therapy
Indications
- Epidermolysis Bullosa Dystrophica
- Junctional Epidermolysis Bullosa
- Epidermolysis Bullosa Dystrophica
Dosing
Epidermolysis Bullosa Dystrophica, Junctional Epidermolysis Bullosa Apply a 1 mm layer to the affected wound surface only; do not rub in the gel; cover with a sterile non-adhesive wound dressing; apply with each wound dressing change until the wound is healed; topical use only, not for use on mucous membranes or eyes.
Epidermolysis Bullosa Dystrophica Applied topically to wounds once weekly; maximum weekly dose 2x10^9 PFU (1 mL) for patients under 3 years, 4x10^9 PFU (2 mL) for patients 3 years and older.
Contraindications
—
—
Adverse Reactions
Most common (>=2%) Application site reaction (application site pruritus, administration site pain, administration site pruritus)
Serious Squamous cell carcinoma of the skin
Most common (>5%) Itching, chills, redness, rash, cough, runny nose
Pharmacology
The mechanism of action of FILSUVEZ in the treatment of wounds associated with epidermolysis bullosa is unknown; pharmacodynamics are also unknown.
HSV-1 vector-based gene therapy that transduces keratinocytes and fibroblasts upon topical wound application, enabling transcription of the encoded human COL7A1 gene and production of type VII collagen (COL7), which assembles into anchoring fibrils that maintain dermal-epidermal integrity.
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Most Common Insurance
Anthem BCBS
Filsuvez
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (10/12)
Vyjuvek
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Filsuvez
- Covered on 4 commercial plans
- PA (5/8) · Step Therapy (0/8) · Qty limit (0/8)
Vyjuvek
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Filsuvez
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Vyjuvek
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAssistance Fund: Epidermolysis Bullosa
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAssistance Fund: Epidermolysis Bullosa
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Next Steps for Your Patient
FilsuvezView full Filsuvez profile
VyjuvekView full Vyjuvek profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.