| Erectile Dysfunction
Viagra vs Edex
Side-by-side clinical, coverage, and cost comparison for erectile dysfunction.Deep comparison between: Viagra vs Edex with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEdex has a higher rate of injection site reactions vs Viagra based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Edex but not Viagra, including UnitedHealthcare
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Category
Viagra
Edex
At A Glance
Oral
As needed, max once daily
PDE5 inhibitor
Intracavernous injection
Up to 3 times weekly
Prostaglandin E1 (PGE1)
Indications
- Erectile Dysfunction
- Erectile dysfunction
Dosing
Erectile Dysfunction 50 mg orally as needed approximately 1 hour before sexual activity (30 minutes to 4 hours prior); may increase to 100 mg or decrease to 25 mg based on effectiveness and toleration; maximum once daily. Consider starting dose of 25 mg in patients >65 years, hepatic impairment, severe renal impairment, or concomitant use of ritonavir or strong CYP3A4 inhibitors.
Erectile dysfunction (vasculogenic, psychogenic, or mixed etiology) Initiate at 2.5 mcg intracavernously; titrate in 2.5-10 mcg increments to effective dose (range 1-40 mcg); inject over 5 to 10 seconds; no more than 3 times weekly with at least 24 hours between doses.
Erectile dysfunction (neurogenic etiology) Initiate at 1.25 mcg intracavernously; titrate in 1.25-5 mcg increments to effective dose (range 1-40 mcg); inject over 5 to 10 seconds; no more than 3 times weekly with at least 24 hours between doses.
Contraindications
- Concomitant use of nitric oxide donors, including organic nitrates or organic nitrites in any form
- Known hypersensitivity to sildenafil or any component of the tablet
- Concomitant use of guanylate cyclase (GC) stimulators, such as riociguat
- Conditions predisposing to priapism, such as sickle cell anemia or sickle cell trait, multiple myeloma, or leukemia
- Fibrotic conditions of the penis, such as cavernosal fibrosis or Peyronie's disease
- Penile implants
Adverse Reactions
Most common (>=2%) headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, rash
Serious cardiovascular and cerebrovascular events, prolonged erection, priapism, sudden decrease or loss of hearing, non-arteritic anterior ischemic optic neuropathy (NAION)
Postmarketing myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, seizure, epistaxis, diplopia, temporary vision loss, vaso-occlusive crisis, hematuria
Most common (>=1%) Penile pain, local bleeding, hematoma, prolonged erection, ecchymosis, penile angulation, penile fibrosis, upper respiratory tract infection, influenza-like symptoms, back pain
Postmarketing Needle breakage
Pharmacology
Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE5) that enhances the effect of nitric oxide by preventing degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, resulting in smooth muscle relaxation and increased blood inflow during sexual stimulation; it has no effect in the absence of sexual stimulation.
Prostaglandin E1 (PGE1) smooth muscle relaxant; induces penile erection by relaxing trabecular smooth muscle and dilating cavernous arteries, expanding lacunar spaces and entrapping blood via the corporal veno-occlusive mechanism.
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Most Common Insurance
Anthem BCBS
Viagra
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (6/12)
Edex
- Covered on 5 commercial plans
- PA (5/12) · Step Therapy (4/12) · Qty limit (0/12)
UnitedHealthcare
Viagra
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Edex
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (3/8)
Humana
Viagra
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Edex
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Viagra.
No savings programs available for Edex.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.