| Essential Hypertension
Azor vs Edarbyclor
Side-by-side clinical, coverage, and cost comparison for essential hypertension.Deep comparison between: Azor vs Edarbyclor with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsEdarbyclor has a higher rate of injection site reactions vs Azor based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Edarbyclor but not Azor, including UnitedHealthcare
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Category
Azor
Edarbyclor
At A Glance
Oral
Once daily
CCB / ARB combination
Oral
Once daily
ARB / thiazide-like diuretic
Indications
- Essential Hypertension
- Essential Hypertension
Dosing
Essential Hypertension Starting dose 5/20 mg once daily; may be increased after 1-2 weeks to a maximum of 10/40 mg once daily as needed to control blood pressure.
Essential Hypertension Starting dose 40/12.5 mg orally once daily; may increase to 40/25 mg after 2 to 4 weeks as needed to achieve blood pressure goals; maximum dose 40/25 mg.
Contraindications
- Co-administration of aliskiren in patients with diabetes
- Anuria
- Coadministration of aliskiren-containing products in patients with diabetes
Adverse Reactions
Most common (>=3%) Edema
Postmarketing (amlodipine) Gynecomastia, jaundice, hepatic enzyme elevations, extrapyramidal disorder
Postmarketing (olmesartan medoxomil) Asthenia, angioedema, anaphylactic reactions, peripheral edema, vomiting, diarrhea, sprue-like enteropathy, hyperkalemia, rhabdomyolysis, acute renal failure, alopecia, pruritus, urticaria
Most common (>=2%) Dizziness, fatigue
Serious Hypotension, syncope, increased serum creatinine, hypokalemia, hyperuricemia
Postmarketing Loss of consciousness, pruritus, angioedema
Pharmacology
Azor combines amlodipine, a dihydropyridine calcium channel blocker that inhibits transmembrane calcium ion influx into vascular smooth muscle and cardiac muscle to reduce peripheral vascular resistance, with olmesartan medoxomil, an angiotensin II receptor blocker that selectively blocks AT1 receptors in vascular smooth muscle to oppose the vasoconstrictor effects of angiotensin II.
Azilsartan is an angiotensin II receptor blocker (ARB) that selectively blocks AT1 receptors to inhibit vasoconstriction and aldosterone secretion; chlorthalidone is a thiazide-like diuretic that inhibits NaCl reabsorption in the distal renal tubule, reducing extracellular fluid volume and blood pressure via complementary mechanisms.
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Most Common Insurance
Anthem BCBS
Azor
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (5/12) · Qty limit (9/12)
Edarbyclor
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (12/12)
UnitedHealthcare
Azor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (1/8)
Edarbyclor
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (4/8)
Humana
Azor
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (2/3) · Qty limit (1/3)
Edarbyclor
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (2/3) · Qty limit (2/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Azor.
No savings programs available for Edarbyclor.
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EdarbyclorView full Edarbyclor profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.