| Febrile Neutropenia
Neulasta vs Rolvedon
Side-by-side clinical, coverage, and cost comparison for febrile neutropenia.Deep comparison between: Neulasta vs Rolvedon with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsRolvedon has a higher rate of injection site reactions vs Neulasta based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Rolvedon but not Neulasta, including UnitedHealthcare
Sign up to reveal the full AI analysis
Category
Neulasta
Rolvedon
At A Glance
SC injection
Once per chemotherapy cycle
G-CSF (colony-stimulating factor)
SC injection
Once per chemotherapy cycle
G-CSF analog
Indications
- Febrile Neutropenia
- Hematopoietic subsyndrome of acute radiation syndrome
- Febrile Neutropenia
Dosing
Febrile Neutropenia 6 mg SC once per chemotherapy cycle for adults and pediatric patients >=45 kg; weight-based dosing (1.5-4 mg SC) for pediatric patients weighing 10-44 kg; 0.1 mg/kg for those <10 kg. Do not administer between 14 days before and 24 hours after chemotherapy.
Hematopoietic Subsyndrome of Acute Radiation Syndrome Two doses of 6 mg each SC one week apart for adults and pediatric patients >=45 kg; weight-based dosing for pediatric patients <45 kg. Administer first dose as soon as possible after suspected or confirmed exposure to radiation >2 Gy, and second dose one week after.
Febrile Neutropenia 13.2 mg SC injection once per chemotherapy cycle, administered approximately 24 hours after cytotoxic chemotherapy; do not administer within the period from 14 days before to 24 hours after cytotoxic chemotherapy.
Contraindications
- History of serious hypersensitivity reaction to pegfilgrastim or filgrastim, including anaphylaxis
- History of serious allergic reactions to eflapegrastim, pegfilgrastim, or filgrastim products, including anaphylaxis
Adverse Reactions
Most common (>=5%) Bone pain, pain in extremity
Serious Splenic rupture, acute respiratory distress syndrome, serious hypersensitivity reactions, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, myelodysplastic syndrome, acute myeloid leukemia, aortitis
Postmarketing Splenic rupture, splenomegaly, ARDS, anaphylaxis, skin rash, urticaria, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, injection site reactions, Sweet's syndrome, cutaneous vasculitis, MDS, AML, aortitis, alveolar hemorrhage
Most common (>=20%) fatigue, nausea, diarrhea, bone pain, headache, pyrexia, anemia, rash, myalgia, arthralgia, back pain
Serious splenic rupture, acute respiratory distress syndrome, serious allergic reactions, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, tumor growth stimulatory effects on malignant cells, MDS and AML, aortitis
Pharmacology
Pegfilgrastim is a PEGylated G-CSF analogue (colony-stimulating factor) that binds specific cell surface receptors on hematopoietic cells, stimulating proliferation, differentiation, commitment, and functional activation; clearance is neutrophil receptor-mediated and nonlinear with dose.
G-CSF analog; eflapegrastim-xnst is a recombinant human granulocyte growth factor that binds to G-CSF receptors on myeloid progenitor cells and neutrophils, triggering signaling pathways that control cell differentiation, proliferation, migration, and survival.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Neulasta
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (1/12) · Qty limit (11/12)
Rolvedon
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Neulasta
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (0/8)
Rolvedon
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Neulasta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Rolvedon
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableCancerCare: Chemotherapy Induced Neutropenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availablePAN: Neutropenia (Medicare)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Compare Other Drugs
Let us handle your prior authsJust enter your patient's info and we'll:
- Verify eligibility with the payer.
- Pull the right PA forms directly from the payer.
- Submit, track & send live updates to your dashboard.
Free to start · HIPAA compliant
Next Steps for Your Patient
NeulastaView full Neulasta profile
RolvedonView full Rolvedon profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.