| Febrile Neutropenia
Nyvepria vs Neulasta
Side-by-side clinical, coverage, and cost comparison for febrile neutropenia.Deep comparison between: Nyvepria vs Neulasta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNeulasta has a higher rate of injection site reactions vs Nyvepria based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Neulasta but not Nyvepria, including UnitedHealthcare
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Category
Nyvepria
Neulasta
At A Glance
SC injection
Once per chemotherapy cycle
Colony-stimulating factor (G-CSF)
SC injection
Once per chemotherapy cycle
G-CSF (colony-stimulating factor)
Indications
- Febrile Neutropenia
- Febrile Neutropenia
- Hematopoietic subsyndrome of acute radiation syndrome
Dosing
Febrile Neutropenia 6 mg SC injection once per chemotherapy cycle; do not administer between 14 days before and 24 hours after cytotoxic chemotherapy; weight-based dosing for pediatric patients weighing less than 45 kg.
Febrile Neutropenia 6 mg SC once per chemotherapy cycle for adults and pediatric patients >=45 kg; weight-based dosing (1.5-4 mg SC) for pediatric patients weighing 10-44 kg; 0.1 mg/kg for those <10 kg. Do not administer between 14 days before and 24 hours after chemotherapy.
Hematopoietic Subsyndrome of Acute Radiation Syndrome Two doses of 6 mg each SC one week apart for adults and pediatric patients >=45 kg; weight-based dosing for pediatric patients <45 kg. Administer first dose as soon as possible after suspected or confirmed exposure to radiation >2 Gy, and second dose one week after.
Contraindications
- History of serious allergic reactions to pegfilgrastim products or filgrastim products, including anaphylaxis
- History of serious hypersensitivity reaction to pegfilgrastim or filgrastim, including anaphylaxis
Adverse Reactions
Most common (>=5%) bone pain, pain in extremity
Serious splenic rupture, acute respiratory distress syndrome, serious allergic reactions, sickle cell disorders, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, myelodysplastic syndrome, acute myeloid leukemia, aortitis
Postmarketing splenic rupture, splenomegaly, ARDS, allergic reactions/hypersensitivity (anaphylaxis, skin rash, urticaria, generalized erythema, flushing), sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, injection site reactions, Sweet's syndrome, cutaneous vasculitis, MDS, AML, aortitis, alveolar hemorrhage
Most common (>=5%) Bone pain, pain in extremity
Serious Splenic rupture, acute respiratory distress syndrome, serious hypersensitivity reactions, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, myelodysplastic syndrome, acute myeloid leukemia, aortitis
Postmarketing Splenic rupture, splenomegaly, ARDS, anaphylaxis, skin rash, urticaria, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, injection site reactions, Sweet's syndrome, cutaneous vasculitis, MDS, AML, aortitis, alveolar hemorrhage
Pharmacology
Pegfilgrastim-apgf is a PEGylated recombinant human G-CSF that binds specific cell surface receptors on hematopoietic cells, stimulating proliferation, differentiation, commitment, and end cell functional activation.
Pegfilgrastim is a PEGylated G-CSF analogue (colony-stimulating factor) that binds specific cell surface receptors on hematopoietic cells, stimulating proliferation, differentiation, commitment, and functional activation; clearance is neutrophil receptor-mediated and nonlinear with dose.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Nyvepria
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Neulasta
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (1/12) · Qty limit (11/12)
UnitedHealthcare
Nyvepria
- Covered on 4 commercial plans
- PA (1/8) · Step Therapy (0/8) · Qty limit (0/8)
Neulasta
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Nyvepria
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Neulasta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableCancerCare: Chemotherapy Induced Neutropenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableCancerCare: Chemotherapy Induced Neutropenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.