| Febrile Neutropenia
Rolvedon vs Neulasta
Side-by-side clinical, coverage, and cost comparison for febrile neutropenia.Deep comparison between: Rolvedon vs Neulasta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNeulasta has a higher rate of injection site reactions vs Rolvedon based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Neulasta but not Rolvedon, including UnitedHealthcare
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Category
Rolvedon
Neulasta
At A Glance
SC injection
Once per chemotherapy cycle
G-CSF analog
SC injection
Once per chemotherapy cycle
G-CSF (colony-stimulating factor)
Indications
- Febrile Neutropenia
- Febrile Neutropenia
- Hematopoietic subsyndrome of acute radiation syndrome
Dosing
Febrile Neutropenia 13.2 mg SC injection once per chemotherapy cycle, administered approximately 24 hours after cytotoxic chemotherapy; do not administer within the period from 14 days before to 24 hours after cytotoxic chemotherapy.
Febrile Neutropenia 6 mg SC once per chemotherapy cycle for adults and pediatric patients >=45 kg; weight-based dosing (1.5-4 mg SC) for pediatric patients weighing 10-44 kg; 0.1 mg/kg for those <10 kg. Do not administer between 14 days before and 24 hours after chemotherapy.
Hematopoietic Subsyndrome of Acute Radiation Syndrome Two doses of 6 mg each SC one week apart for adults and pediatric patients >=45 kg; weight-based dosing for pediatric patients <45 kg. Administer first dose as soon as possible after suspected or confirmed exposure to radiation >2 Gy, and second dose one week after.
Contraindications
- History of serious allergic reactions to eflapegrastim, pegfilgrastim, or filgrastim products, including anaphylaxis
- History of serious hypersensitivity reaction to pegfilgrastim or filgrastim, including anaphylaxis
Adverse Reactions
Most common (>=20%) fatigue, nausea, diarrhea, bone pain, headache, pyrexia, anemia, rash, myalgia, arthralgia, back pain
Serious splenic rupture, acute respiratory distress syndrome, serious allergic reactions, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, tumor growth stimulatory effects on malignant cells, MDS and AML, aortitis
Most common (>=5%) Bone pain, pain in extremity
Serious Splenic rupture, acute respiratory distress syndrome, serious hypersensitivity reactions, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, myelodysplastic syndrome, acute myeloid leukemia, aortitis
Postmarketing Splenic rupture, splenomegaly, ARDS, anaphylaxis, skin rash, urticaria, sickle cell crisis, glomerulonephritis, leukocytosis, thrombocytopenia, capillary leak syndrome, injection site reactions, Sweet's syndrome, cutaneous vasculitis, MDS, AML, aortitis, alveolar hemorrhage
Pharmacology
G-CSF analog; eflapegrastim-xnst is a recombinant human granulocyte growth factor that binds to G-CSF receptors on myeloid progenitor cells and neutrophils, triggering signaling pathways that control cell differentiation, proliferation, migration, and survival.
Pegfilgrastim is a PEGylated G-CSF analogue (colony-stimulating factor) that binds specific cell surface receptors on hematopoietic cells, stimulating proliferation, differentiation, commitment, and functional activation; clearance is neutrophil receptor-mediated and nonlinear with dose.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Rolvedon
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Neulasta
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (1/12) · Qty limit (11/12)
UnitedHealthcare
Rolvedon
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Neulasta
- Covered on 4 commercial plans
- PA (2/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Rolvedon
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Neulasta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availablePAN: Neutropenia (Medicare)
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableCancerCare: Chemotherapy Induced Neutropenia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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RolvedonView full Rolvedon profile
NeulastaView full Neulasta profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.