| Gaucher Disease, Type 1
Cerdelga vs Cerezyme
Side-by-side clinical, coverage, and cost comparison for gaucher disease, type 1.Deep comparison between: Cerdelga vs Cerezyme with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsCerezyme has a higher rate of injection site reactions vs Cerdelga based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Cerezyme but not Cerdelga, including UnitedHealthcare
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Category
Cerdelga
Cerezyme
At A Glance
Oral
Once or twice daily
Glucosylceramide synthase inhibitor
IV infusion
3x/week to every 2 weeks
Glucocerebrosidase (enzyme replacement)
Indications
- Gaucher Disease, Type 1
- Gaucher Disease, Type 1
- Gaucher Disease, Type 3
Dosing
Gaucher Disease, Type 1 EMs and IMs: 84 mg orally twice daily; PMs: 84 mg orally once daily; dose frequency may be reduced to once daily in EMs and IMs taking concomitant CYP2D6 or CYP3A inhibitors depending on hepatic impairment status.
Gaucher Disease, Type 1, Gaucher Disease, Type 3 2.5 units/kg three times a week to 60 units/kg once every two weeks, administered intravenously; titrate based on disease severity and therapeutic goals.
Contraindications
- EMs taking a strong or moderate CYP2D6 inhibitor concomitantly with a strong or moderate CYP3A inhibitor
- EMs with moderate or severe hepatic impairment
- EMs with mild hepatic impairment taking a strong or moderate CYP2D6 inhibitor
- IMs taking a strong or moderate CYP2D6 inhibitor concomitantly with a strong or moderate CYP3A inhibitor
- IMs taking a strong CYP3A inhibitor
- IMs with any degree of hepatic impairment
- PMs taking a strong CYP3A inhibitor
- PMs with any degree of hepatic impairment
—
Adverse Reactions
Most common (>=10%) fatigue, headache, nausea, diarrhea, back pain, pain in extremities, upper abdominal pain
Most common headache, dizziness, tachycardia, flushing, hypotension, hypertension, cough, dyspnea, abdominal pain, diarrhea, nausea, vomiting, pruritus, rash, urticaria, back pain, chest discomfort, chills, fatigue, infusion-site burning, infusion-site discomfort, infusion-site swelling, pyrexia
Serious anaphylaxis, hypersensitivity reactions, pneumonia, pulmonary hypertension, angioedema, cyanosis
Pharmacology
Eliglustat is a specific inhibitor of glucosylceramide synthase (IC50 = 10 ng/mL) that acts as a substrate reduction therapy for Gaucher disease type 1 by reducing the production of glucosylceramide (GL-1), thereby alleviating GL-1 accumulation in the liver, spleen, bone marrow, and other target organs.
Imiglucerase is a recombinant analogue of human beta-glucocerebrosidase that catalyzes the hydrolysis of glucocerebroside to glucose and ceramide; mannose-terminated oligosaccharide chains mediate binding to and uptake into macrophages and other target cells, replacing deficient enzyme activity in Gaucher disease.
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Most Common Insurance
Anthem BCBS
Cerdelga
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (9/12)
Cerezyme
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Cerdelga
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Cerezyme
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Cerdelga
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Cerezyme
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Gaucher Disease - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Gaucher Disease - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.