| Glaucoma, Open-Angle
Cosopt PF vs Durysta
Side-by-side clinical, coverage, and cost comparison for glaucoma, open-angle.Deep comparison between: Cosopt Pf vs Durysta with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsDurysta has a higher rate of injection site reactions vs Cosopt Pf based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Durysta but not Cosopt Pf, including UnitedHealthcare
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Category
Cosopt Pf
Durysta
At A Glance
Ophthalmic
Twice daily
Carbonic anhydrase inhibitor / beta-blocker
Intracameral implant
Single dose
Prostaglandin analog
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) twice daily; if other topical ophthalmic drugs are used, administer at least 5 minutes apart. Use the contents of each individual unit immediately after opening and discard any remaining solution.
Glaucoma, Open-Angle, Ocular Hypertension Single biodegradable intracameral implant (10 mcg bimatoprost) administered once into the anterior chamber under aseptic conditions; do not readminister to a previously treated eye.
Contraindications
- Bronchial asthma or history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Hypersensitivity to any component of this product
- Active or suspected ocular or periocular infections
- Corneal endothelial cell dystrophy (e.g., Fuchs' Dystrophy)
- Prior corneal transplantation or endothelial cell transplants (e.g., DSAEK)
- Absent or ruptured posterior lens capsule (risk of implant migration into the posterior segment)
- Hypersensitivity to bimatoprost or any other component of the product
Adverse Reactions
Most common (>=5%) Taste perversion (bitter, sour, or unusual taste), ocular burning and/or stinging (up to 30%), conjunctival hyperemia, blurred vision, superficial punctate keratitis, eye itching (5-15%)
Postmarketing Bradycardia, cardiac failure, cerebral vascular accident, chest pain, choroidal detachment following filtration surgery, depression, diarrhea, dry mouth, dyspnea, heart block, hypotension, iridocyclitis, myocardial infarction, nasal congestion, Stevens-Johnson syndrome, toxic epidermal necrolysis, paresthesia, photophobia, respiratory failure, skin rashes, urolithiasis, vomiting
Most common (>=5%) Conjunctival hyperemia (27%), foreign body sensation, eye pain, photophobia, conjunctival hemorrhage, dry eye, eye irritation, increased IOP, corneal endothelial cell loss, blurred vision, iritis, headache
Serious Implant migration, hypersensitivity, corneal adverse reactions, macular edema, intraocular inflammation, pigmentation, endophthalmitis
Postmarketing Endophthalmitis
Pharmacology
COSOPT PF combines dorzolamide hydrochloride (carbonic anhydrase II inhibitor) and timolol maleate (non-selective beta1/beta2-adrenergic receptor blocker); both components independently reduce elevated intraocular pressure by decreasing aqueous humor secretion, with additive IOP-lowering effect when combined.
Bimatoprost is a prostaglandin analog with ocular hypotensive activity that lowers IOP by increasing aqueous humor outflow through both the trabecular meshwork (conventional) and uveoscleral (unconventional) routes.
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Most Common Insurance
Anthem BCBS
Cosopt Pf
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Durysta
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Cosopt Pf
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Durysta
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Cosopt Pf
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Durysta
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Cosopt Pf.
$0/fillfill
Durysta CoPay Assistance ProgramCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Cosopt PfView full Cosopt Pf profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.