| Glaucoma, Open-Angle
Cosopt PF vs Lumigan
Side-by-side clinical, coverage, and cost comparison for glaucoma, open-angle.Deep comparison between: Cosopt Pf vs Lumigan with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsLumigan has a higher rate of injection site reactions vs Cosopt Pf based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Lumigan but not Cosopt Pf, including UnitedHealthcare
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Category
Cosopt Pf
Lumigan
At A Glance
Ophthalmic
Twice daily
Carbonic anhydrase inhibitor / beta-blocker
Ophthalmic
Once daily
Prostaglandin analog
Indications
- Glaucoma, Open-Angle
- Ocular Hypertension
- Glaucoma, Open-Angle
- Ocular Hypertension
Dosing
Glaucoma, Open-Angle, Ocular Hypertension One drop in the affected eye(s) twice daily; if other topical ophthalmic drugs are used, administer at least 5 minutes apart. Use the contents of each individual unit immediately after opening and discard any remaining solution.
Glaucoma, Open-Angle; Ocular Hypertension One drop in the affected eye(s) once daily in the evening; if used concomitantly with other topical ophthalmic drugs, administer at least 5 minutes apart.
Contraindications
- Bronchial asthma or history of bronchial asthma, or severe chronic obstructive pulmonary disease
- Sinus bradycardia, second or third degree atrioventricular block, overt cardiac failure, or cardiogenic shock
- Hypersensitivity to any component of this product
- Hypersensitivity to bimatoprost or any excipient
Adverse Reactions
Most common (>=5%) Taste perversion (bitter, sour, or unusual taste), ocular burning and/or stinging (up to 30%), conjunctival hyperemia, blurred vision, superficial punctate keratitis, eye itching (5-15%)
Postmarketing Bradycardia, cardiac failure, cerebral vascular accident, chest pain, choroidal detachment following filtration surgery, depression, diarrhea, dry mouth, dyspnea, heart block, hypotension, iridocyclitis, myocardial infarction, nasal congestion, Stevens-Johnson syndrome, toxic epidermal necrolysis, paresthesia, photophobia, respiratory failure, skin rashes, urolithiasis, vomiting
Most common (>=1%) Conjunctival hyperemia, conjunctival edema, conjunctival hemorrhage, eye irritation, eye pain, eye pruritus, erythema of eyelid, eyelid pruritus, growth of eyelashes, hypertrichosis, instillation site irritation, punctate keratitis, skin hyperpigmentation, blurred vision, reduced visual acuity
Postmarketing Asthma-like symptoms, dizziness, dry eye, dyspnea, eye discharge, eye edema, foreign body sensation, headache, hypersensitivity, hypertension, increased lacrimation, periorbital and lid changes, photophobia
Pharmacology
COSOPT PF combines dorzolamide hydrochloride (carbonic anhydrase II inhibitor) and timolol maleate (non-selective beta1/beta2-adrenergic receptor blocker); both components independently reduce elevated intraocular pressure by decreasing aqueous humor secretion, with additive IOP-lowering effect when combined.
Bimatoprost is a prostaglandin analog that lowers intraocular pressure by increasing aqueous humor outflow through both the trabecular meshwork and uveoscleral routes, selectively mimicking naturally occurring prostamides.
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Most Common Insurance
Anthem BCBS
Cosopt Pf
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (9/12)
Lumigan
- Covered on 5 commercial plans
- PA (1/12) · Step Therapy (1/12) · Qty limit (9/12)
UnitedHealthcare
Cosopt Pf
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Lumigan
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (2/8)
Humana
Cosopt Pf
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (2/3) · Qty limit (2/3)
Lumigan
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (1/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Cosopt Pf.
No savings programs available for Lumigan.
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Cosopt PfView full Cosopt Pf profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.