| Glycogen storage disease type II
Lumizyme vs Nexviazyme
Side-by-side clinical, coverage, and cost comparison for glycogen storage disease type ii.Deep comparison between: Lumizyme vs Nexviazyme with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsNexviazyme has a higher rate of injection site reactions vs Lumizyme based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Nexviazyme but not Lumizyme, including UnitedHealthcare
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Category
Lumizyme
Nexviazyme
At A Glance
IV infusion
Every 2 weeks
GAA enzyme replacement
IV infusion
Every 2 weeks
Recombinant acid alpha-glucosidase
Indications
- Glycogen storage disease type II
- Glycogen storage disease type II
Dosing
Glycogen storage disease type II 20 mg/kg every 2 weeks as an intravenous infusion; initial infusion rate no more than 1 mg/kg/hour, titrated by 2 mg/kg/hour every 30 minutes as tolerated to a maximum of 7 mg/kg/hour.
Glycogen storage disease type II 20 mg/kg IV every 2 weeks for patients >=30 kg; 40 mg/kg IV every 2 weeks for patients <30 kg; consider pretreatment with antihistamines, antipyretics, and/or corticosteroids to reduce infusion-associated reaction risk.
Contraindications
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Adverse Reactions
Most common (>=5%) anaphylaxis, rash, pyrexia, flushing/feeling hot, urticaria, headache, hyperhidrosis, nausea, cough, decreased oxygen saturation, tachycardia, tachypnea, chest discomfort, dizziness, muscle twitching, agitation, cyanosis, erythema, hypertension/increased blood pressure, pallor, rigors, tremor, vomiting, fatigue, myalgia
Serious anaphylaxis, acute cardiorespiratory failure
Postmarketing anaphylactic shock, respiratory failure, respiratory arrest, cardiac arrest, hypoxia, dyspnea, wheezing, convulsions, proteinuria, nephrotic syndrome secondary to membranous glomerulonephritis, necrotizing skin lesions, hyperparathyroidism
Most common (>5%) abdominal pain, arthralgia, chills, diarrhea, dizziness, dyspnea, erythema, fatigue, flushing, headache, hypertension, hypotension, myalgia, nausea, pruritus, pyrexia, rash, vomiting, urticaria
Serious respiratory distress, chills, pyrexia; severe hypersensitivity reactions (anaphylaxis) including chest discomfort, generalized edema, hypotension, hypoxia, tongue edema, urticaria
Pharmacology
Alglucosidase alfa provides an exogenous source of acid alpha-glucosidase (GAA); it binds to mannose-6-phosphate receptors on the cell surface, is internalized and transported into lysosomes where proteolytic cleavage increases enzymatic activity, and then cleaves lysosomal glycogen to address the GAA deficiency underlying Pompe disease.
Pompe disease results from deficiency of lysosomal acid alpha-glucosidase (GAA), causing intralysosomal glycogen accumulation in multiple tissues. Avalglucosidase alfa-ngpt is a recombinant human GAA engineered with high-density mannose-6-phosphate (M6P) glycans that bind M6P receptors with high affinity, enabling cellular internalization and lysosomal transport where it undergoes proteolytic activation and cleaves accumulated glycogen.
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Most Common Insurance
Anthem BCBS
Lumizyme
- Covered on 5 commercial plans
- PA (12/12) · Step Therapy (0/12) · Qty limit (0/12)
Nexviazyme
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Lumizyme
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Nexviazyme
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Lumizyme
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Nexviazyme
- Covered on 0 commercial plans
- PA (2/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Pompe Disease - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Pompe Disease - Private Insurance
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.