| Hemophilia A
Altuviiio vs Hympavzi
Side-by-side clinical, coverage, and cost comparison for hemophilia a.Deep comparison between: Altuviiio vs Hympavzi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsHympavzi has a higher rate of injection site reactions vs Altuviiio based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Hympavzi but not Altuviiio, including UnitedHealthcare
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Category
Altuviiio
Hympavzi
At A Glance
IV infusion
Once weekly
Recombinant factor VIII
SC injection
Weekly
TFPI antagonist
Indications
- Hemophilia A
- Hemophilia A
- Hemophilia B
Dosing
Hemophilia A - Routine Prophylaxis 50 IU/kg IV once weekly for adults and children.
Hemophilia A - On-demand (Minor and Moderate Bleeding) Single dose of 50 IU/kg IV; a lower dose of 30 IU/kg may be used for bleeds occurring within 2 to 3 days after a prophylactic dose; additional doses of 30 or 50 IU/kg every 2 to 3 days may be considered.
Hemophilia A - On-demand (Major Bleeding) Single dose of 50 IU/kg IV; additional doses of 30 or 50 IU/kg every 2 to 3 days may be considered.
Hemophilia A - Perioperative (Minor Surgery) Pre-operative: single dose of 50 IU/kg IV; post-operative: an additional dose of 30 or 50 IU/kg after 2 to 3 days may be considered.
Hemophilia A - Perioperative (Major Surgery) Pre-operative: single dose of 50 IU/kg IV; post-operative: additional doses of 30 or 50 IU/kg every 2 to 3 days as clinically needed.
Hemophilia A, Hemophilia B Loading dose 300 mg SC (two 150 mg injections); maintenance 150 mg SC once weekly starting one week after loading dose; consider dose adjustment to 300 mg SC weekly in patients >=50 kg with inadequate bleeding control.
Contraindications
- Severe hypersensitivity reactions, including anaphylaxis, to ALTUVIIIO or any of its excipients
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Adverse Reactions
Most common (>10%) Headache, arthralgia (adults and adolescents); pyrexia (children below 12 years)
Serious Thromboembolic events (1% of patients in long-term extension, in patients with pre-existing risk factors)
Postmarketing Factor VIII inhibitor development, hypersensitivity reactions including anaphylaxis
Most common (>=3%) Injection site reaction, headache, pruritus
Serious Thromboembolic events, hypersensitivity, peripheral swelling, venous thrombosis
Pharmacology
Recombinant FVIII Fc-VWF-XTEN fusion protein that temporarily replaces missing coagulation factor VIII to restore hemostasis in hemophilia A; half-life is extended 3- to 4-fold over standard FVIII products through Fc-FcRn recycling, VWF D'D3 domain shielding from endogenous VWF, and XTEN-mediated reduction in clearance.
Marstacimab-hncq is a human monoclonal IgG1 antibody that targets the Kunitz domain 2 (K2) of tissue factor pathway inhibitor (TFPI), neutralizing TFPI activity and enhancing thrombin generation via the extrinsic coagulation pathway.
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Most Common Insurance
Anthem BCBS
Altuviiio
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (0/12) · Qty limit (0/12)
Hympavzi
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Altuviiio
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (0/8) · Qty limit (0/8)
Hympavzi
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (3/8)
Humana
Altuviiio
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Hympavzi
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (1/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availableAccessia Health: Inherited and Acquired Factor Deficiencies - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
Cost estimate not availableAccessia Health: Inherited and Acquired Factor Deficiencies - Private Insurance: Waitlist
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
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AltuviiioView full Altuviiio profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.