| Hepatitis C, Chronic
Alvaiz vs Vosevi
Side-by-side clinical, coverage, and cost comparison for hepatitis c, chronic.Deep comparison between: Alvaiz vs Vosevi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVosevi has a higher rate of injection site reactions vs Alvaiz based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vosevi but not Alvaiz, including UnitedHealthcare
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Category
Alvaiz
Vosevi
At A Glance
Oral
Daily
TPO-receptor agonist
Oral
Once daily
NS5B polymerase + NS5A + NS3/4A protease inhibitor combination
Indications
- Immune thrombocytopenic purpura
- Hepatitis C, Chronic
- Severe Aplastic Anemia
- Hepatitis C, Chronic
Dosing
Immune thrombocytopenic purpura Initiate at 36 mg orally once daily (18 mg for East-/Southeast-Asian ancestry or hepatic impairment; 9 mg for both); adjust in 18-mg increments to maintain platelet count >=50 x 10^9/L; maximum 54 mg daily.
Hepatitis C, Chronic Initiate at 18 mg orally once daily; adjust in 18-mg increments every 2 weeks to achieve platelet count needed to initiate or maintain pegylated interferon and ribavirin therapy; maximum 72 mg daily; discontinue when antiviral therapy is discontinued.
Severe Aplastic Anemia Initiate at 36 mg orally once daily (18 mg for East-/Southeast-Asian ancestry or hepatic impairment); adjust in 36-mg increments every 2 weeks to maintain platelet count >=50 x 10^9/L; maximum 108 mg daily.
Chronic Hepatitis C (genotype 1-6, NS5A inhibitor-experienced) One tablet (400 mg sofosbuvir, 100 mg velpatasvir, 100 mg voxilaprevir) orally once daily with food for 12 weeks
Chronic Hepatitis C (genotype 1a or 3, sofosbuvir without NS5A inhibitor) One tablet (400 mg sofosbuvir, 100 mg velpatasvir, 100 mg voxilaprevir) orally once daily with food for 12 weeks
Contraindications
—
- Coadministration with rifampin
Adverse Reactions
Most common (>=3%) Nausea, diarrhea, upper respiratory tract infection, vomiting, urinary tract infection, increased ALT, myalgia, oropharyngeal pain, increased AST, pharyngitis, back pain, influenza, paresthesia, rash
Serious Hemorrhage, thrombotic/thromboembolic complications, hepatic decompensation, hepatotoxicity, cataracts
Postmarketing Skin discoloration including hyperpigmentation and skin yellowing
Most common (>=10%) Headache, fatigue, diarrhea, nausea
Serious Symptomatic bradycardia when coadministered with amiodarone, hepatic decompensation, hepatic failure
Postmarketing Skin rashes with blisters or angioedema-like swelling, angioedema
Pharmacology
Eltrombopag is a TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor (cMpl), initiating signaling cascades that induce proliferation and differentiation of megakaryocytes, leading to increased platelet production.
VOSEVI is a fixed-dose combination of three direct-acting antivirals: sofosbuvir (NS5B polymerase inhibitor), velpatasvir (NS5A inhibitor), and voxilaprevir (NS3/4A protease inhibitor) that target distinct steps in the HCV replication cycle.
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Most Common Insurance
Anthem BCBS
Alvaiz
- Covered on 5 commercial plans
- PA (9/12) · Step Therapy (9/12) · Qty limit (1/12)
Vosevi
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (10/12) · Qty limit (11/12)
UnitedHealthcare
Alvaiz
- Covered on 4 commercial plans
- PA (4/8) · Step Therapy (4/8) · Qty limit (0/8)
Vosevi
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (4/8) · Qty limit (7/8)
Humana
Alvaiz
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (2/3) · Qty limit (3/3)
Vosevi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
Cost estimate not availablePAF Co-Pay Relief: Aplastic Anemia
Commercial or private insurance
Medicare, Medicaid, VA, TRICARE
$5/fillfill
Gilead Support Path Co-pay Coupon: VoseviCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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AlvaizView full Alvaiz profile
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.