| Hepatitis C, Chronic
Harvoni vs Vosevi
Side-by-side clinical, coverage, and cost comparison for hepatitis c, chronic.Deep comparison between: Harvoni vs Vosevi with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsVosevi has a higher rate of injection site reactions vs Harvoni based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Vosevi but not Harvoni, including UnitedHealthcare
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Category
Harvoni
Vosevi
At A Glance
Oral
Once daily
NS5A inhibitor + NS5B polymerase inhibitor
Oral
Once daily
NS5B polymerase + NS5A + NS3/4A protease inhibitor combination
Indications
- Hepatitis C, Chronic
- Hepatitis C, Chronic
Dosing
Hepatitis C, Chronic (Genotype 1, treatment-naive or treatment-experienced without cirrhosis or with compensated cirrhosis) 90 mg ledipasvir/400 mg sofosbuvir orally once daily for 12 weeks (8 weeks may be considered in treatment-naive patients without cirrhosis with HCV RNA <6 million IU/mL); 24 weeks in treatment-experienced with compensated cirrhosis
Hepatitis C, Chronic (Genotype 1, with decompensated cirrhosis) 90 mg ledipasvir/400 mg sofosbuvir orally once daily + ribavirin for 12 weeks
Hepatitis C, Chronic (Genotype 1 or 4, liver transplant recipients) 90 mg ledipasvir/400 mg sofosbuvir orally once daily + ribavirin for 12 weeks
Hepatitis C, Chronic (Genotype 4, 5, or 6, without cirrhosis or with compensated cirrhosis) 90 mg ledipasvir/400 mg sofosbuvir orally once daily for 12 weeks
Chronic Hepatitis C (genotype 1-6, NS5A inhibitor-experienced) One tablet (400 mg sofosbuvir, 100 mg velpatasvir, 100 mg voxilaprevir) orally once daily with food for 12 weeks
Chronic Hepatitis C (genotype 1a or 3, sofosbuvir without NS5A inhibitor) One tablet (400 mg sofosbuvir, 100 mg velpatasvir, 100 mg voxilaprevir) orally once daily with food for 12 weeks
Contraindications
- When administered with ribavirin, all contraindications to ribavirin apply to the combination regimen
- Coadministration with rifampin
Adverse Reactions
Most common (>=10%) Fatigue, headache
Serious Serious symptomatic bradycardia when coadministered with amiodarone
Postmarketing Skin rashes, sometimes with blisters or angioedema-like swelling, angioedema
Most common (>=10%) Headache, fatigue, diarrhea, nausea
Serious Symptomatic bradycardia when coadministered with amiodarone, hepatic decompensation, hepatic failure
Postmarketing Skin rashes with blisters or angioedema-like swelling, angioedema
Pharmacology
Ledipasvir inhibits the HCV NS5A protein required for viral replication, and sofosbuvir inhibits the HCV NS5B RNA-dependent RNA polymerase, which is also required for viral replication.
VOSEVI is a fixed-dose combination of three direct-acting antivirals: sofosbuvir (NS5B polymerase inhibitor), velpatasvir (NS5A inhibitor), and voxilaprevir (NS3/4A protease inhibitor) that target distinct steps in the HCV replication cycle.
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Most Common Insurance
Anthem BCBS
Harvoni
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
Vosevi
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (10/12) · Qty limit (11/12)
UnitedHealthcare
Harvoni
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (4/8) · Qty limit (7/8)
Vosevi
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (4/8) · Qty limit (7/8)
Humana
Harvoni
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Vosevi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Harvoni.
$5/fillfill
Gilead Support Path Co-pay Coupon: VoseviCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.