| Hepatitis C, Chronic
Vosevi vs Harvoni
Side-by-side clinical, coverage, and cost comparison for hepatitis c, chronic.Deep comparison between: Vosevi vs Harvoni with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsHarvoni has a higher rate of injection site reactions vs Vosevi based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Harvoni but not Vosevi, including UnitedHealthcare
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Category
Vosevi
Harvoni
At A Glance
Oral
Once daily
NS5B polymerase + NS5A + NS3/4A protease inhibitor combination
Oral
Once daily
NS5A inhibitor + NS5B polymerase inhibitor
Indications
- Hepatitis C, Chronic
- Hepatitis C, Chronic
Dosing
Chronic Hepatitis C (genotype 1-6, NS5A inhibitor-experienced) One tablet (400 mg sofosbuvir, 100 mg velpatasvir, 100 mg voxilaprevir) orally once daily with food for 12 weeks
Chronic Hepatitis C (genotype 1a or 3, sofosbuvir without NS5A inhibitor) One tablet (400 mg sofosbuvir, 100 mg velpatasvir, 100 mg voxilaprevir) orally once daily with food for 12 weeks
Hepatitis C, Chronic (Genotype 1, treatment-naive or treatment-experienced without cirrhosis or with compensated cirrhosis) 90 mg ledipasvir/400 mg sofosbuvir orally once daily for 12 weeks (8 weeks may be considered in treatment-naive patients without cirrhosis with HCV RNA <6 million IU/mL); 24 weeks in treatment-experienced with compensated cirrhosis
Hepatitis C, Chronic (Genotype 1, with decompensated cirrhosis) 90 mg ledipasvir/400 mg sofosbuvir orally once daily + ribavirin for 12 weeks
Hepatitis C, Chronic (Genotype 1 or 4, liver transplant recipients) 90 mg ledipasvir/400 mg sofosbuvir orally once daily + ribavirin for 12 weeks
Hepatitis C, Chronic (Genotype 4, 5, or 6, without cirrhosis or with compensated cirrhosis) 90 mg ledipasvir/400 mg sofosbuvir orally once daily for 12 weeks
Contraindications
- Coadministration with rifampin
- When administered with ribavirin, all contraindications to ribavirin apply to the combination regimen
Adverse Reactions
Most common (>=10%) Headache, fatigue, diarrhea, nausea
Serious Symptomatic bradycardia when coadministered with amiodarone, hepatic decompensation, hepatic failure
Postmarketing Skin rashes with blisters or angioedema-like swelling, angioedema
Most common (>=10%) Fatigue, headache
Serious Serious symptomatic bradycardia when coadministered with amiodarone
Postmarketing Skin rashes, sometimes with blisters or angioedema-like swelling, angioedema
Pharmacology
VOSEVI is a fixed-dose combination of three direct-acting antivirals: sofosbuvir (NS5B polymerase inhibitor), velpatasvir (NS5A inhibitor), and voxilaprevir (NS3/4A protease inhibitor) that target distinct steps in the HCV replication cycle.
Ledipasvir inhibits the HCV NS5A protein required for viral replication, and sofosbuvir inhibits the HCV NS5B RNA-dependent RNA polymerase, which is also required for viral replication.
Enter your patient's insuranceCheck specific coverage details for your patient.
Most Common Insurance
Anthem BCBS
Vosevi
- Covered on 5 commercial plans
- PA (11/12) · Step Therapy (10/12) · Qty limit (11/12)
Harvoni
- Covered on 5 commercial plans
- PA (10/12) · Step Therapy (10/12) · Qty limit (9/12)
UnitedHealthcare
Vosevi
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (4/8) · Qty limit (7/8)
Harvoni
- Covered on 4 commercial plans
- PA (7/8) · Step Therapy (4/8) · Qty limit (7/8)
Humana
Vosevi
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Harvoni
- Covered on 0 commercial plans
- PA (3/3) · Step Therapy (3/3) · Qty limit (3/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
$5/fillfill
Gilead Support Path Co-pay Coupon: VoseviCommercial or private insurance
Medicare, Medicaid, VA, TRICARE
No savings programs available for Harvoni.
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Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.